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Physiological Reviews
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#2Ethan A. Lerner (Harvard University)H-Index: 32
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Itch is a topic to which everyone can relate. The physiologic roles of itch are increasingly understood and appreciated. The pathophysiologic consequences of itch impact quality of life as much as ...
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#1Susan M. WallH-Index: 32
#2Jill W. VerlanderH-Index: 37
Last. Cesar A. RomeroH-Index: 1
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Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl(-) absorption and HCO3(-) secretion, largely through the anion exchanger pendrin. This exchanger is thought to act in tandem with the Na(+)-dependent Cl(-)/HCO3(-) exchanger, NDCBE, to mediate net NaCl absorption. Pendrin is stimulated by angiotensin II and aldosterone administration via the a...
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#1Onur Güntürkün (RUB: Ruhr University Bochum)H-Index: 59
#2Felix Ströckens (RUB: Ruhr University Bochum)H-Index: 8
Last. Sebastian Ocklenburg (RUB: Ruhr University Bochum)H-Index: 23
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Comparative studies on brain asymmetry date back to the 19th century but then largely disappeared due to the assumption that lateralization is uniquely human. Since the reemergence of this field in the 1970s, we learned that left-right differences of brain and behavior exist throughout the animal kingdom and pay off in terms of sensory, cognitive, and motor efficiency. Ontogenetically, lateralization starts in many species with asymmetrical expression patterns of genes within the Nodal cascade t...
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#1Andrew Barker (UAB: University of Alabama at Birmingham)H-Index: 1
#2Brant M. Wagener (UAB: University of Alabama at Birmingham)H-Index: 12
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#2Ronald J. WongH-Index: 35
Last. David K. StevensonH-Index: 76
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#1T. Alexander Quinn (Dal: Dalhousie University)H-Index: 17
#2Peter Kohl (University of Freiburg)H-Index: 50
The heart is vital for biological function in almost all chordates, including human. It beats continually throughout our life, supplying the body with oxygen and nutrients while removing waste products. If it stops - so does life. The heartbeat involves precise coordination of the activity of billions of individual cells, as well as their swift and well-coordinated adaption to changes in physiological demand. Much of the vital control of cardiac function occurs at the level of individual cardiac...
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#1Nati Hernando (UZH: University of Zurich)H-Index: 30
#2Kenneth B. Gagnon (University of Louisville)H-Index: 2
Last. Eleanor D. Lederer (University of Louisville)H-Index: 24
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Phosphate is an essential nutrient for life and is a critical component of bone formation, a major signaling molecule, and structural component of cell walls. Phosphate is also a component of high-energy compounds (i.e. AMP, ADP, and ATP), and essential for nucleic acid helical structure (i.e. RNA and DNA). Phosphate plays a central role in the process of mineralization, normal serum levels being associated with appropriate bone mineralization, while high and low serum levels are associated with...
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#1Roberto Papait (University of Insubria)H-Index: 15
#2Simone Serio (Humanitas University)
Last. Gianluigi Condorelli (Humanitas University)H-Index: 65
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Gene expression is needed for the maintenance of heart function under normal conditions and in response to stress. Each cell type of the heart has a specific program controlling transcription. Different types of stress induce modifications of these programs, and if prolonged, can lead to altered cardiac phenotype and, eventually, to heart failure. The transcriptional status of a gene is regulated by the epigenome, a complex network of DNA and histone modifications. Until a few years ago, our und...
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#1Christian Giaume (Collège de France)H-Index: 52
#2Christian C. NausH-Index: 59
Last. Luc Leybaert (UGent: Ghent University)H-Index: 51
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Over the past several decades a large amount of data have established that glial cells, the main cell population in the brain, dynamically interact with neurons and thus impact their activity and survival. One typical feature of glia is their marked expression of several connexins, the membrane proteins forming intercellular gap junction channels and hemichannels. Pannexins, which have a tetraspan membrane topology as connexins, are also detected in glial cells. Here, we review the evidence that...
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#1Elisabeth HessmannH-Index: 10
#2Sören M. BuchholzH-Index: 1
Last. Albrecht NeesseH-Index: 17
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Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment (TME) that dynamically evolves during tumor progression. The TME consists of different non-neoplastic cells such as cancer-associated fibroblasts (CAFs), immune cells, endothelial cells and neurons. Furthermore, abundant extracellular matrix (ECM) components such as collagen and hyaluronic acid (HA) as well as matricellular pr...
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