Total flavonoids from celery suppresses RANKL-induced osteoclast differentiation and bone resorption function via attenuating NF-κB and p38 pathways in RAW264.7 cells

Skeletal diseases caused by excessive activation of osteoclasts seriously affect elderly’s health. Therefore, inhibiting excessive activation of osteoclasts become effective therapeutic strategy for osteoporosis. Celery, a traditional and popular Chinese vegetable with high nutritional value, is rich in flavonoids which have a variety of pharmacological activities. The present study aimed to determine the pharmacological effect of total...