Angiotensin receptor neprolysin inhibitors: a novel approach to prevent cardiorenal disease in diabetes mellitus

Despite significant improvement in diagnosis and therapy, diabetes mellitus remains a major public health burden. Among all the diabetic complications, cardiovascular (CVD) and chronic kidney diseases (CKD) represent the major serious causes of morbidity and mortality [1]. Diabetic kidney disease, classified as proteinuric and nonproteinuric diabetic nephropathy, represents the leading cause of CKD and accounts for about 40–50% of new patients...