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Mesoporous silica particles as potential carriers for protein drug delivery: protein immobilisation and the effect of displacer on γ-globulin release

Published on Mar 12, 2020in Drug Development and Industrial Pharmacy2.367
· DOI :10.1080/03639045.2020.1742141
Adejumoke Lara Ajiboye1
Estimated H-index: 1
(University of Greenwich),
Vivek Trivedi9
Estimated H-index: 9
(Medway School of Pharmacy),
John C. Mitchell30
Estimated H-index: 30
(University of Greenwich)
Abstract
AbstractThe adsorption of γ-globulin was evaluated with experiments with silica particles marketed as Syloid AL1-FP (SAL), XDP-3150 (SXDP), and 244FP (SFP). The influence of pH, pore sizes, and deg...
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Abstract In this study, phenylboronic acid-modified magnetic fibrous mesoporous silica (MFMS-P) was successfully synthesized by an improved one-step oil–water biphase stratification coating strategy using a precise velocity control device. The transmission electron microscopy images showed particles composed of a Fe3O4 core (150–200 nm), nonporous silica interlayer (50 nm), and a fibrous shell (110 nm), exhibiting radial-like direct channels and ideal pore size (12.72–13.58 nm). The adsorption b...
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Abstract Novel zwitterionic surface modified mesoporous silica nanoparticles (MSNs) were prepared for alendronate release. Phospholipid moieties were generated by the ring-opening reaction of 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) subsequent to (3-bromopropyl) trimethoxysilane immobilisation. Studies confirmed the successful introduction of phosphorylcholine (PC) groups at the surface without sacrificing the original structure of MCM41. The adsorption of bovine serum albumin was reduced sig...
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To investigate the molecular interactions of sodium dodecyl sulfate (SDS) with human ubiquitin and its unfolding mechanisms, a comparative study was conducted on the interactions of the protein in the presence and absence of SDS at different temperatures using six independent 500 ns atomistic molecular dynamics (MD) simulations. Moreover, the effects of partial atomic charges on SDS aggregation and micellar structures were investigated at high SDS concentrations. The results demonstrated that hu...
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A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this interaction have been investigated, like size and ζ potential. However, NPs exposure concentration has always been ignored. Herein, we aim to disclose the correlation of NPs exposure concentration with protein adsorption.Four polymeric NPs systems possessing similar sizes (230 ± 20 nm) but varied ζ potentials (-30 ∼ +40 mv) were prepared. Physicoche...
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A study on the adsorption of proteins from fetal bovine serum (FBS) on spherical dense and mesoporous silica nanoparticles with a wide range of diameters, from 70 to 900 nm, is presented. Monodisperse populations of particles with a range of diameters were obtained through modifications of the Stober method. Extensive characterization of the particles was then performed using N2 physisorption, TEM, DLS, and ζ-potential. Following serum exposure, proteomic evaluation in concert with thermogravime...
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In this study we have investigated the suitability of a number of different mesoporous silica nanoparticle structures for carrying a drug cargo. We have fully characterized the nanoparticles in terms of their physical parameters; size, surface area, internal pore size and structure. These data are all required if we are to make an informed judgement on the suitability of the structure for drug delivery in vivo. With these parameters in mind, we investigated the loading/unloading profile of a mod...
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