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Vivek Trivedi
University of Greenwich
Supercritical fluidOrganic chemistryChemistryDifferential scanning calorimetryChromatography
29Publications
9H-index
209Citations
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Publications 30
Newest
#1Adejumoke Lara Ajiboye (University of Greenwich)H-Index: 1
#2Vivek Trivedi (Medway School of Pharmacy)H-Index: 9
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 3 authors...
AbstractThe adsorption of γ-globulin was evaluated with experiments with silica particles marketed as Syloid AL1-FP (SAL), XDP-3150 (SXDP), and 244FP (SFP). The influence of pH, pore sizes, and deg...
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#1Vivek TrivediH-Index: 9
#2Ruchir BhomiaH-Index: 4
Last. John C. MitchellH-Index: 30
view all 3 authors...
Solid core drug delivery systems (SCDDS) were prepared for the oral delivery of biomolecules using mesoporous silica as core, bovine haemoglobin (bHb) as model drug and supercritical fluid (SCF) processing as encapsulation technique. The use of organic solvents or harsh processing conditions in the development of drug delivery systems for biomolecules can be detrimental for the structural integrity of the molecule. Hence, the coating on protein-immobilised particles was performed via supercritic...
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#1Adejumoke Lara Ajiboye (University of Greenwich)H-Index: 1
#2Vivek Trivedi (University of Greenwich)H-Index: 9
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 3 authors...
Polycaprolactone (PCL) nanoparticles were produced via supercritical fluid extraction of emulsions (SFEE) using supercritical carbon dioxide (scCO2). The efficiency of the scCO2 extraction was investigated and compared to that of solvent extraction at atmospheric pressure. The effects of process parameters including polymer concentration (0.6–10% w/w in acetone), surfactant concentration (0.07 and 0.14% w/w) and polymer-to-surfactant weight ratio (1:1–16:1 w/w) on the particle size and surface m...
1 CitationsSource
#1Vivek Trivedi (University of Greenwich)H-Index: 9
#2Uttom Nandi (University of Greenwich)H-Index: 3
Last. Nichola J. Coleman (University of Greenwich)H-Index: 18
view all 4 authors...
On the basis of their large specific surface areas, high adsorption and cation exchange capacities, swelling potential and low toxicity, natural smectite clays are attractive substrates for the gastric protection of neutral and cationic drugs. Theophylline is an amphoteric xanthine derivative that is widely used as a bronchodilator in the treatment of asthma and chronic obstructive pulmonary disease. This study considers the in vitro uptake and release characteristics of the binary theophylline-...
3 CitationsSource
#1Sajjad Khan (University of Greenwich)H-Index: 4
#2Vivek Trivedi (University of Greenwich)H-Index: 9
Last. Joshua S. Boateng (University of Greenwich)H-Index: 23
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Abstract This study involves the development of thin oral solvent cast films for the potential delivery of the proton pump inhibitor, omeprazole (OME) via the buccal mucosa for paediatric patients. OME containing films were prepared from ethanolic gels (1% w/w) of metolose (MET) with polyethylene glycol (PEG 400) (0.5% w/w) as plasticiser, and L-arginine ( l -arg) (0.2% w/w) as a stabilizer and dried in an oven at 40 °C. The blank and drug loaded films were divided into two groups, one group was...
4 CitationsSource
#1Ruchir Bhomia (University of Greenwich)H-Index: 4
#2Vivek Trivedi (University of Greenwich)H-Index: 9
Last. John C. Mitchell (University of Greenwich)H-Index: 30
view all 4 authors...
Abstract The effects of temperature, pH and long-term storage on the secondary structure and conformation changes of bovine haemoglobin (bHb) were studied using circular dichroism (CD) and ultraviolet--visible (UV–vis) spectroscopies. Neural network software was used to deconvolute the CD data to obtain the fractional content of the five secondary structures. The storage stability of bHb solutions in pH 6, 7 and 8 buffers was significantly higher at 4 °C than at 23 °C for the first 3 days. A com...
12 CitationsSource
#1Shashi Ravi Suman Rudrangi (University of Greenwich)H-Index: 5
#2Waseem Kaialy (University of Wolverhampton)H-Index: 19
Last. Bruce D. Alexander (University of Greenwich)H-Index: 17
view all 6 authors...
The aim of this study was to enhance the apparent solubility and dissolution properties of flurbiprofen through inclusion complexation with cyclodextrins. Especially, the efficacy of supercritical fluid technology as a preparative technique for the preparation of flurbiprofen-methyl–β–cyclodextrin inclusion complexes was evaluated. The complexes were prepared by supercritical carbon dioxide processing and were evaluated by solubility, differential scanning calorimetry, X-ray powder diffraction, ...
8 CitationsSource
#1Abir Bouledjouidja (AMU: Aix-Marseille University)H-Index: 2
#2Yasmine Masmoudi (AMU: Aix-Marseille University)H-Index: 6
Last. Elisabeth Badens (AMU: Aix-Marseille University)H-Index: 13
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The drug delivery through intraocular lenses (IOLs) allows the combination of cataract surgery act and postoperative treatment in a single procedure. In order to prepare such systems, “clean” supercritical CO2 processes are studied for loading commercial IOLs with ophthalmic drugs. Ciprofloxacin (CIP, an antibiotic) and dexamethasone 21-phosphate disodium (DXP, an anti-inflammatory drug) were impregnated into foldable IOLs made from poly-2-hydroxyethyl methacrylate (P-HEMA). A first pre-treatmen...
15 CitationsSource
#1Sajjad Khan (University of Greenwich)H-Index: 4
#2Vivek Trivedi (University of Greenwich)H-Index: 9
Last. Joshua S. Boateng (University of Greenwich)H-Index: 23
view all 3 authors...
Buccal films were prepared from aqueous and ethanolic Metolose gels using the solvent casting approach (40 °C). The hydration (PBS and simulated saliva), mucoadhesion, physical stability (20 °C, 40 °C), in vitro drug (omeprazole) dissolution (PBS and simulated saliva), ex vivo permeation (pig buccal mucosa) in the presence of simulated saliva, ex vivo bioadhesion and cell viability using MTT of films were investigated. Hydration and mucoadhesion results showed that swelling capacity and adhesion...
15 CitationsSource
#1Tammy Savage (University of Greenwich)H-Index: 1
#2John C. Mitchell (University of Greenwich)H-Index: 30
Last. Laura J. Waters (University of Huddersfield)H-Index: 19
view all 5 authors...
Batch synthesis of sulphobutyl ether β-cyclodextrin (also known as SBE-β-CD or SBECD) is a process effectively divided into three main stages, i.e. initial reagent dissolution, a sulphoalkylation reaction and final reaction quenching. This reaction is followed by downstream processing and purification, and ultimate isolation of the solid SBECD material. However, a feature associated with using this synthetic method is that a high proportion of lower substituted SBECD is observed. There is theref...
1 CitationsSource
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