Review paper
[Medical treatment options in BRCA-associated cancers].
Abstract
Germinal or somatic mutations of the BRCA genes may serve as therapeutic targets. Deficient functioning of the BRCA genes render the cancer vulnerable to such therapeutic interventions as chemotherapy with DNA-targeted agents and PARP inhibitors targeting DNA repair capacity. Although BRCA mutations may be detected in a large variety of cancers, the mentioned specific therapies are efficient in the so called BRCA-associated cancers only...
Paper Details
Title
[Medical treatment options in BRCA-associated cancers].
Published Date
Mar 17, 2020
Journal
Volume
64
Issue
1
Pages
13 - 24
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Notes
History