Original paper
d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
Abstract
The broad-spectrum antibiotic D-cycloserine (DCS) is a key component of regimens used to treat multi- and extensively drug-resistant tuberculosis. DCS, a structural analog of D-alanine, binds to and inactivates two essential enzymes involved in peptidoglycan biosynthesis, alanine racemase (Alr) and D-Ala:D-Ala ligase. Inactivation of Alr is thought to proceed via a mechanism-based irreversible route, forming an adduct with the pyridoxal...
Paper Details
Title
d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
Published Date
Mar 16, 2020
Journal
Volume
16
Issue
6
Pages
686 - 694
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Notes
History