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Luiz Pedro S. de Carvalho
Francis Crick Institute
35Publications
11H-index
436Citations
Publications 38
Newest
#1Dimitrios Evangelopoulos (Francis Crick Institute)H-Index: 2
#2Gareth A. Prosser (University of Manchester)
Last.Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 2
view all 9 authors...
Drug resistant infections represent one of the most challenging medical problems of our time. D-cycloserine is an antibiotic used for six decades without significant appearance and dissemination of antibiotic resistant strains, making it an ideal model compound to understand what drives resistance evasion. We therefore investigated why Mycobacterium tuberculosis fails to become resistant to D-cycloserine. To address this question, we employed a combination of bacterial genetics, genomics, bioche...
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#1Agnese Serafini (Francis Crick Institute)H-Index: 2
#2Lendl Tan (UQ: University of Queensland)H-Index: 4
Last.Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 2
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Bacterial nutrition is an essential aspect of host–pathogen interaction. For the intracellular pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans, fatty acids derived from lipid droplets are considered the major carbon source. However, many other soluble nutrients are available inside host cells and may be used as alternative carbon sources. Lactate and pyruvate are abundant in human cells and fluids, particularly during inflammation. In this work, we study ...
4 CitationsSource
#1Hua Wang (Francis Crick Institute)H-Index: 3
#2Alexander A. Fedorov (Albert Einstein College of Medicine)H-Index: 40
Last.Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 11
view all 10 authors...
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infection, macrophages produce metabolites with the purpose of inhibiting or killing the bacterial cell. Itaconate is an abundant host metabolite thought to be both an antimicrobial agent and a modulator of the host inflammatory response. However, the exact mode of act...
2 CitationsSource
#1Safaa M. Kishk (Cardiff University)H-Index: 1
#2Safaa M. Kishk (Cardiff University)H-Index: 1
Last.Claire Simons (Cardiff University)H-Index: 21
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The emergence of untreatable drug‐resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450 CYP121A1 is a promising drug target for the treatment of tuberculosis owing to its essential role in mycobacterial growth. Using a rational approach, which includes molecular modelling studies, three series of azole pyrazole derivatives were designed through t...
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#1Safaa M. Kishk (Cardiff University)H-Index: 1
#2Kirsty J. McLean (University of Manchester)H-Index: 18
Last.Claire Simons (Cardiff University)H-Index: 21
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Abstract The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis ( Mtb ) revealed twenty different genes coding for cytochrome P450s. CYP121A1 catalyzes a C C crosslinking reaction of dicyclotyrosine (cYY) producing mycocyclosin and current research suggests that either mycocyclosin is essential or the overproduction of cYY is toxic to Mtb . A series...
1 CitationsSource
#1Diana FreireH-Index: 2
#2Claude Gutierrez (University of Toulouse)H-Index: 9
Last.Olivier Neyrolles (University of Toulouse)H-Index: 41
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Summary Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. We report a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis. The toxin, MbcT, is bactericidal unless neutralized by its antitoxin MbcA. To investigate the mechanism, we solved the 1.8 A-resolution crystal structure of the MbcTA complex. We found that MbcT resembles secreted NAD+-dependent bacterial exotoxins, such as diphthe...
2 CitationsSource
#1Diana FreireH-Index: 2
#2Claude GutierrezH-Index: 9
Last.Olivier NeyrollesH-Index: 41
view all 8 authors...
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#1Aleksandra Agapova (Francis Crick Institute)H-Index: 1
#2Agnese Serafini (Francis Crick Institute)H-Index: 2
Last.Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 11
view all 7 authors...
Tuberculosis is an infectious disease caused by a bacterium called Mycobacterium tuberculosis. It is currently the leading cause of death by a single microbe worldwide, claiming the lives of 1.5 million people annually. The disease is difficult to cure, as many strains of the bacterium have developed resistance to the main drugs used to treat the infection. This leaves physicians with few options to treat tuberculosis and control its spread. The spread of these drug-resistant strains is a major ...
4 CitationsSource
#1Aleksandra Agapova (Francis Crick Institute)H-Index: 1
#2Agnese Serafini (Francis Crick Institute)H-Index: 2
Last.Luiz Pedro S. de Carvalho (Francis Crick Institute)H-Index: 11
view all 7 authors...
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#1Amy Switzer (Imperial College London)H-Index: 3
#2Dimitrios Evangelopoulos (Francis Crick Institute)H-Index: 2
Last.Sivaramesh Wigneshweraraj (Imperial College London)H-Index: 17
view all 6 authors...
The initial adaptive transcriptional response to nitrogen (N) starvation in Escherichia coli involves large-scale alterations to the transcriptome mediated by the transcriptional activator, NtrC. One of these NtrC-activated genes is yeaG, which encodes a conserved bacterial kinase. Although it is known that YeaG is required for optimal survival under sustained N starvation, the molecular basis by which YeaG benefits N starved E. coli remains elusive. By combining transcriptomics with targeted me...
3 CitationsSource
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