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Luiz Pedro S. de Carvalho
Francis Crick Institute
Publications 42
Published in Molecular Microbiology 3.65
Agnese Serafini (Francis Crick Institute), Lendl Tan4
Estimated H-index: 4
(UQ: University of Queensland)
+ -3 AuthorsChristine R. Montague4
Estimated H-index: 4
(Cornell University)
Hua Wang2
Estimated H-index: 2
(Francis Crick Institute),
Alexander A. Fedorov40
Estimated H-index: 40
(Albert Einstein College of Medicine)
+ 7 AuthorsLuiz Pedro S. de Carvalho14
Estimated H-index: 14
(Francis Crick Institute)
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infection, macrophages produce metabolites with the purpose of inhibiting or killing the bacterial cell. Itaconate is an abundant host metabolite thought to be both an antimicrobial agent and a modulator of the host inflammatory response. However, the exact mode of act...
Published on Jul 8, 2019in Nature microbiology 14.30
Yoshikazu Kawai14
Estimated H-index: 14
(Newcastle University),
Romain Mercier12
Estimated H-index: 12
(AMU: Aix-Marseille University)
+ 3 AuthorsJeff Errington59
Estimated H-index: 59
(Newcastle University)
The peptidoglycan cell wall is an essential structure for the growth of most bacteria. However, many are capable of switching into a wall-deficient L-form state in which they are resistant to antibiotics that target cell wall synthesis under osmoprotective conditions, including host environments. L-form cells may have an important role in chronic or recurrent infections. The cellular pathways involved in switching to and from the L-form state remain poorly understood. This work shows that the la...
Published on Jul 1, 2019in ChemistryOpen 2.21
Safaa M. Kishk (Cardiff University), Kirsty J. McLean + 10 AuthorsLuiz Pedro S. de Carvalho14
Estimated H-index: 14
(Francis Crick Institute)
Published on Apr 1, 2019in Journal of Experimental Medicine 10.89
Stephanie R. Lovell-Read (University of Oxford), Luiz Pedro S. de Carvalho14
Estimated H-index: 14
(Francis Crick Institute)
Published on Feb 1, 2019in Bioorganic & Medicinal Chemistry 2.80
Safaa M. Kishk (Cardiff University), Kirsty J. McLean29
Estimated H-index: 29
(University of Manchester)
+ 7 AuthorsAndrew W. Munro47
Estimated H-index: 47
(University of Manchester)
Abstract The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis ( Mtb ) revealed twenty different genes coding for cytochrome P450s. CYP121A1 catalyzes a C C crosslinking reaction of dicyclotyrosine (cYY) producing mycocyclosin and current research suggests that either mycocyclosin is essential or the overproduction of cYY is toxic to Mtb . A series...
Published on Apr 1, 2019in Molecular Microbiology 3.65
Samantha L. van der Beek2
Estimated H-index: 2
(UU: Utrecht University),
Azul Zorzoli (Dund.: University of Dundee)+ 8 AuthorsHelge C. Dorfmueller12
Estimated H-index: 12
(Dund.: University of Dundee)
Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS) and Streptococcus mutans. Those pathogens require dTDP-L-rhamnose for the production of structurally similar rhamnose polysaccharides in their cell wall. Via heterologous expression in S. mutans, we confirm that GAS RmlB and RmlC are critical for dTDP-L-rhamnose biosynthesis through their action...
Published on Mar 1, 2019in Molecular Cell 14.55
Diana Mendes Freire1
Estimated H-index: 1
Claude Gutierrez9
Estimated H-index: 9
(University of Toulouse)
+ 20 AuthorsVivian Pogenberg10
Estimated H-index: 10
Summary Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. We report a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis. The toxin, MbcT, is bactericidal unless neutralized by its antitoxin MbcA. To investigate the mechanism, we solved the 1.8 A-resolution crystal structure of the MbcTA complex. We found that MbcT resembles secreted NAD + -dependent bacterial exotoxins, such as dipht...
Published on Mar 1, 2019in Journal of Biological Chemistry
Uday Tak1
Estimated H-index: 1
(UAB: University of Alabama at Birmingham),
Jiri Vlach4
Estimated H-index: 4
(UAB: University of Alabama at Birmingham)
+ 5 AuthorsMichael Niederweis40
Estimated H-index: 40
(UAB: University of Alabama at Birmingham)
Published on Jan 31, 2019in eLife 7.55
Aleksandra Agapova (Francis Crick Institute), Agnese Serafini (Francis Crick Institute)+ 4 AuthorsLuiz Pedro S. de Carvalho14
Estimated H-index: 14
(Francis Crick Institute)
Tuberculosis is an infectious disease caused by a bacterium called Mycobacterium tuberculosis. It is currently the leading cause of death by a single microbe worldwide, claiming the lives of 1.5 million people annually. The disease is difficult to cure, as many strains of the bacterium have developed resistance to the main drugs used to treat the infection. This leaves physicians with few options to treat tuberculosis and control its spread. The spread of these drug-resistant strains is a major ...