Direct measurement of vertical forces shows correlation between mechanical activity and proteolytic ability of invadopodia
Abstract
Mechanobiology plays a prominent role in cancer invasion and metastasis. The ability of a cancer to degrade extracellular matrix (ECM) is likely connected to its invasiveness. Many cancer cells form invadopodia-micrometer-sized cellular protrusions that promote invasion through matrix degradation (proteolysis). Although it has been hypothesized that invadopodia exert mechanical force that is implicated in cancer invasion, direct measurements...
Paper Details
Title
Direct measurement of vertical forces shows correlation between mechanical activity and proteolytic ability of invadopodia
Published Date
Mar 13, 2020
Journal
Volume
6
Issue
11
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