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Eleni Dalaka
University of St Andrews
Extracellular matrixInvadopodiaMetastasisMechanobiologySquamous carcinoma
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#1Eleni Dalaka (St And: University of St Andrews)
#2Nils M. Kronenberg (St And: University of St Andrews)H-Index: 14
Last. Malte C. Gather (St And: University of St Andrews)H-Index: 34
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Mechanobiology plays a prominent role in cancer invasion and metastasis. The ability of a cancer to degrade extracellular matrix (ECM) is likely connected to its invasiveness. Many cancer cells form invadopodia—micrometer-sized cellular protrusions that promote invasion through matrix degradation (proteolysis). Although it has been hypothesized that invadopodia exert mechanical force that is implicated in cancer invasion, direct measurements remain elusive. Here, we use a recently developed inte...
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