Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips

Successful translation of potential cancer chemotherapeutic drugs to the clinic depends on sufficient predictability of response in the human system through in vitro simulations. High expenditure and longer duration in preclinical and clinical research urge the enhancement of effective in vitro drug screening. 3D models emulate cell morphology, cell–cell and cell–matrix interactions and are physiologically more relevant for predicting drug...