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Drug Discovery Today
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#1Yongtao Duan (Boston Children's Hospital)H-Index: 4
#2Yongfang Yao (Zhengzhou University)
Last. Junbiao Chang (Zhengzhou University)
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#1Md. Hafiz Uddin (WSU: Wayne State University)
#2Jeffrey A. Zonder (WSU: Wayne State University)H-Index: 31
Last. Asfar S. Azmi (WSU: Wayne State University)H-Index: 42
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Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the nucleus of host cell and reduce virus replication and immunopathogenicity. These observations support the concept of the inhibition of nuclear export...
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#1Christos Ermogenous (University of Birmingham)
#2Charlotte Green (Dund.: University of Dundee)H-Index: 11
Last. Janet M. LordH-Index: 56
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Patients with multimorbidities have shorter life expectancy and their clinical management is more complex and expensive for healthcare systems currently focused on treating single diseases. Given that age is the major risk factor for multimorbidity, the challenge of treating these patients will only increase in coming years. Here, we review the case for targeting the core processes that drive the ageing phenotype as a novel pharmaceutical approach to multimorbidity. There is growing evidence tha...
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