Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily
Abstract
The rapid increase of multidrug resistance poses urgent threats to human health. Multidrug transporters prompt multidrug resistance by exporting different therapeutics across cell membranes, often by utilizing the H+ electrochemical gradient. MdfA from Escherichia coli is a prototypical H+ -dependent multidrug transporter belonging to the Major Facilitator Superfamily. Prior studies revealed unusual flexibility in the coupling between multidrug...
Paper Details
Title
Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily
Published Date
Mar 3, 2020
Journal
Volume
10
Issue
1
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