Food antigens and Transglutaminase 2 in IgA nephropathy: Molecular links between gut and kidney
Abstract
The transglutaminase 2 (TG2) is one of the enigmatic enzymes with important functional diversity. It plays an important role in several pathologies such as celiac disease (CD). In patients with active CD, the abnormal retrotranscytosis of IgA/gliadin complexes is mediated by Transferrin Receptor 1 (TfR1). This triad association takes also place in IgA nephropathy (IgA-N). IgA-N is characterized by the formation of nephrotoxic complexes of IgA1...
Paper Details
Title
Food antigens and Transglutaminase 2 in IgA nephropathy: Molecular links between gut and kidney
Published Date
May 1, 2020
Journal
Volume
121
Pages
1 - 6
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