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Molecular Immunology
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#1Deniz Cagdas (Hacettepe University)H-Index: 9
#2Naz Surucu (METU: Middle East Technical University)H-Index: 1
Last. Burcu Balci-Hayta (Hacettepe University)H-Index: 4
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Abstract Introduction H Syndrome is an autosomal recessive (AR) disease caused by defects in SLCA29A3 gene. This gene encodes the equilibrative nucleoside transporter, the protein which is highly expressed in spleen, lymph node and bone marrow. Autoinflammation and autoimmunity accompanies H Syndrome (HS). Aim The aim was to further elucidate the mechanisms of disease by molecular studies in a patient with SLC29A3 gene defect. Patient and Methods Mitochondrial dysfunction, lysosomal integrity, c...
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#1Da AoH-Index: 1
#2Shuangjie LiH-Index: 2
Last. Jianzhong ZhuH-Index: 1
view all 7 authors...
Abstract To study the interrelationship between the signaling adaptors of innate pattern recognition receptor (PRR) pathways including toll-like receptor (TLR), retinoic acid-inducible gene-1-like receptor (RLR), nucleotide-binding oligomerization domain-like receptor (NLR), and cytoplasmic DNA recognition receptors (CDR) pathways. The coding genes of porcine TRIF, MAVS, STING, MyD88, RIPK2, and ASC were isolated from PK15 cells. Phylogenetic analysis of the six adaptor proteins in pig, cattle, ...
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#1Shaoxuan WangH-Index: 1
Last. Fulai WangH-Index: 1
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Abstract Ulcerative colitis (UC) is characterized by a relapsing and remitting pattern. The remission phase may last weeks to years. It remains unclear what specific factors can cause the disease to exist the remission phase and enter an activated state. IL-10 is a cytokine best known for its anti-inflammatory roles. We hypothesized that IL-10 might have a role in suppressing disease flares in UC remission patients. Unexpectedly, we found that UC remission patients with higher serum IL-10 levels...
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#1Lilia Abbad (French Institute of Health and Medical Research)H-Index: 3
#2Renato C. Monteiro (French Institute of Health and Medical Research)H-Index: 34
Last. Laureline Berthelot (University of Nantes)H-Index: 3
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Abstract The transglutaminase 2 (TG2) is one of the enigmatic enzymes with important functional diversity. It plays an important role in several pathologies such as celiac disease (CD). In patients with active CD, the abnormal retrotranscytosis of IgA/gliadin complexes is mediated by Transferrin Receptor 1 (TfR1). This triad association takes also place in IgA nephropathy (IgA-N). IgA-N is characterized by the formation of nephrotoxic complexes of IgA1 and soluble CD89 (sCD89). These complexes a...
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#1Ashutosh Vats (NDRI: National Dairy Research Institute)H-Index: 2
#2Devika Gautam (NDRI: National Dairy Research Institute)H-Index: 1
Last. Sachinandan De (NDRI: National Dairy Research Institute)H-Index: 16
view all 8 authors...
Abstract The innate immune system is activated upon virus invasion of a host cell by recognizing viral component, such as dsRNA through specific receptors, resulting in the production of type- I IFNs, which confer an antiviral state within the invaded as well as surrounding cells. In the present study, fibroblast, monocyte and macrophage cells derived from water Buffalo (Bubalus bubalis) were exposed to a synthetic dsRNA analogue, poly I:C to mimic viral invasion in each cell type. Recognition o...
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#1Laura J. Myhill (UCPH: University of Copenhagen)H-Index: 1
#2Penille Jensen (UCPH: University of Copenhagen)
Last. Andrew R. Williams (UCPH: University of Copenhagen)H-Index: 12
view all 9 authors...
Abstract Consumption of fermentable dietary fibres, such as inulin, or administration of helminth products (e.g. Trichuris suis ova) have independently been shown to alleviate inflammation in vivo. We recently found that dietary inulin and T. suis infection in pigs co-operatively suppressed type-1 inflammatory responses in the gut, suggesting the potential of dietary components to augment anti-inflammatory responses induced by certain helminths. Here, we explored whether T. suis antigens and inu...
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#1Yrvin León (UdeC: University of Concepción)
#2Lionel Zapata (UdeC: University of Concepción)
Last. Angel Oñate (UdeC: University of Concepción)H-Index: 12
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Abstract Shigellosis is a diarrheal disease that causes high mortality every year, especially in children, elderly and immunocompromised patients. Recently, resistance strains to antibiotic therapy are in the rise and the World Health Organization prioritizes the development of a safe vaccine against the most common causal agent of shigellosis, Shigella flexneri. This pathogen uses autotransporter proteins such as SigA, Pic and Sap to increase virulence and some of them have been described as hi...
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#1Jian DuH-Index: 1
#2Wei LvH-Index: 1
Last. Ji-Yan LengH-Index: 1
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Abstract Myocardial infarction (MI) or heart attack is a deadly event with high prevalence. In the present study, we investigated the effects of the polypeptide copolymer glatiramer acetate (GA) in H9c2 rat cardiomyocytes exposed to oxygen-glucose deprivation/reperfusion injury. Immediately following MI, an acute inflammatory response is triggered that causes activation of various proinflammatory cytokines, infiltration of immune cells, and neovascularization. This response is largely mediated b...
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#1Tianwei ZhanH-Index: 2
#2Tao-Feng WeiH-Index: 1
Last. Ming WuH-Index: 5
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Abstract Pulmonary fibrosis is a progressive chronic inflammatory lung disease whose pathogenesis is complicated. Platelets and neutrophils play important roles in the progression of pulmonary inflammation. We have reported that cangrelor, a non-sepesific GPR17 antagonist, alleviates pulmonary fibrosis partly by inhibiting macrophage inflammation in mice. Cangrelor is also a well-known anti-platelet agent. To test whether cangrelor mitigated pulmonary fibrosis partly through the inhibition of pl...
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#1Kira Dobrochaeva (RAS: Russian Academy of Sciences)H-Index: 2
#2Nailya Khasbiullina (RAS: Russian Academy of Sciences)H-Index: 5
Last. Alexander FilatovH-Index: 7
view all 14 authors...
Abstract To understand the role of human natural IgM known as antibodies against the carbohydrate epitope Tn, the antibodies were isolated using GalNAcα−Sepharose affinity chromatography, and their specificity was profiled using microarrays (a glycan array printed with oligosaccharides and bacterial polysaccharides, as well as a glycopeptide array), flow cytometry, and inhibition ELISA. The antibodies bound a restricted number of GalNAcα-terminated oligosaccharides better than the parent monosac...
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