Small-molecule drug repurposing to target DNA damage repair and response pathways
Abstract
For decades genotoxic therapy has been a mainstay in the treatment of cancer, based on the understanding that the deregulated growth and genomic instability that drive malignancy also confer a shared vulnerability. Although chemotherapy and radiation can be curative, only a fraction of patients benefit, while nearly all are subjected to the harmful side-effects. Drug repurposing, defined here as retooling existing drugs and compounds as chemo or...
Paper Details
Title
Small-molecule drug repurposing to target DNA damage repair and response pathways
Published Date
Jan 1, 2021
Journal
Volume
68
Pages
230 - 241
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Notes
History