Whole Genome Sequencing Analyses Identify SIDT2 Loss-of-function Mutations In Patients with Eczema Herpeticum

Eczema herpeticum (EH) can be a devastating complication of atopic dermatitis (AD) associated with disseminated herpes simplex virus (HSV) infection. The role of rare genetic variants in disease etiology is largely unknown. This study aimed to identify rare variants that are associated with AD patients with a history of recurrent EH (ADEH+). Genome sequences of 49 recurrent ADEH+ ((≥3 EH episodes), 491 AD without a history of eczema herpeticum...