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Rasika A. Mathias
Johns Hopkins University
281Publications
44H-index
12.2kCitations
Publications 281
Newest
#1Sven J. van der Lee (EUR: Erasmus University Rotterdam)H-Index: 24
#2Maria J. Knol (EUR: Erasmus University Rotterdam)H-Index: 3
Last.Charles D. Smith (UC Davis: University of California, Davis)H-Index: 122
view all 62 authors...
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocamp...
#1Michelle Daya (University of Colorado Denver)H-Index: 10
#2Nicholas Rafaels (University of Colorado Denver)H-Index: 26
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 65 authors...
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find ...
#1Meher Preethi Boorgula (University of Colorado Denver)H-Index: 9
#2Margaret A. Taub (Johns Hopkins University)H-Index: 18
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 21 authors...
Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with eczema herpeticum (ADEH+). We will determine how methylation varies in AD individuals with/without EH and associated traits. We modeled differences in genome-wide DNA methylation in whole blood cells from 90 ADEH+, 83 ADEH−, and 84 non-atopic, healthy control subjects, replicating in 36 ADEH+...
#1Michelle Daya (University of Colorado Denver)H-Index: 10
#2Caapa (University of Colorado Denver)
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 66 authors...
#1Chloé Sarnowski (BU: Boston University)H-Index: 5
#2Aaron Leong (Broad Institute)H-Index: 16
Last.James B. Meigs (Broad Institute)H-Index: 127
view all 42 authors...
Hemoglobin A1c (HbA1c) is widely used to diagnose diabetes and assess glycemic control in individuals with diabetes. However, nonglycemic determinants, including genetic variation, may influence how accurately HbA1c reflects underlying glycemia. Analyzing the NHLBI Trans-Omics for Precision Medicine (TOPMed) sequence data in 10,338 individuals from five studies and four ancestries (6,158 Europeans, 3,123 African-Americans, 650 Hispanics, and 407 East Asians), we confirmed five regions associated...
#1Alexander G. Bick (Harvard University)H-Index: 19
#2Joshua S. Weinstock (UM: University of Michigan)H-Index: 1
Last.Sekar Kathiresan (Broad Institute)H-Index: 106
view all 123 authors...
Age is the dominant risk factor for most chronic human diseases; yet the mechanisms by which aging confers this risk are largely unknown. Recently, the age-related acquisition of somatic mutations in regenerating hematopoietic stem cell populations was associated with both hematologic cancer incidence and coronary heart disease prevalence. Somatic mutations with leukemogenic potential may confer selective cellular advantages leading to clonal expansion, a phenomenon termed 9Clonal Hematopoiesis ...
#1Margaret A. Taub (Johns Hopkins University)H-Index: 18
#2Joshua S. Weinstock (UM: University of Michigan)H-Index: 1
Last.Rasika A. Mathias (Johns Hopkins University)H-Index: 44
view all 125 authors...
Telomeres shorten in replicating somatic cells and with age; in human leukocytes, telomere length (TL) is associated with a host of aging-related diseases. To date, 16 genome-wide association studies (GWAS) have identified twenty-three loci associated with leukocyte TL, but prior studies were primarily in individuals of European and Asian ancestry and relied on laboratory assays including Southern Blot and qPCR to quantify TL. Here, we estimated TL bioinformatically, leveraging whole genome sequ...
#1Brian G Kral (Johns Hopkins University)H-Index: 17
#2Diane M. Becker (Johns Hopkins University)H-Index: 51
Last.Rita R. Kalyani (Johns Hopkins University)H-Index: 26
view all 7 authors...
Abstract Aim Type 2 diabetes (T2DM) in a first-degree relative is a risk factor for incident diabetes. Americans of African ancestry (AA) have higher rates of T2DM than Americans of European ancestry (EA). Thus, we aimed to determine whether the presence, number and kinship of affected relatives are associated with race-specific T2DM incidence in a prospective study of participants from the Genetic Study of Atherosclerosis Risk (GeneSTAR), who underwent baseline screening including a detailed fa...
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