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Self-assembled peptide nanoparticles for efficient delivery of methotrexate into cancer cells.

Published on Mar 5, 2020in Drug Development and Industrial Pharmacy2.367
· DOI :10.1080/03639045.2020.1734017
Ali Shirani3
Estimated H-index: 3
(Tabriz University of Medical Sciences),
Ali Nokhodchi43
Estimated H-index: 43
(University of Sussex)
+ 7 AuthorsHadi Valizadeh29
Estimated H-index: 29
(Tabriz University of Medical Sciences)
Abstract
The low cellular uptake of Methotrexate (MTX), a commonly used anticancer drug, is a big challenge for efficient cancer therapy. Self-assembled peptide nanoparticles (SAPNs) are one of the ...
  • References (40)
  • Citations (0)
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References40
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Developing safe and efficient non-viral delivery systems remains a major challenge for in vivo applications of gene therapy, especially in cystic fibrosis. Unlike conventional cationic polymers or lipids, the emerging poloxamine-based copolymers display promising in vivo gene delivery capabilities. However, poloxamines are invalid for in vitro applications and their in vivo transfection efficiency is still low compared with viral vectors. Here, we show that peptides developed by modular design a...
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#1Guo-Bin Qi (Center for Excellence in Education)H-Index: 6
#2Yu-Juan Gao (Center for Excellence in Education)H-Index: 11
Last. Hao Wang (Center for Excellence in Education)H-Index: 29
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#1Masoud Farshbaf (NIMR: National Institute for Medical Research)H-Index: 6
#2Roya Salehi (Tabriz University of Medical Sciences)H-Index: 19
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AbstractIn the current study, we proposed a facile method for fabrication of multifunctional pH- and thermo-sensitive magnetic nanocomposites (MNCs) as a theranostic agent for using in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe3O4 magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo-sensitive properties, respectively. We also conjugated mesoporous sili...
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#1Deepthi Poornima Budagavi (IITD: Indian Institute of Technology Delhi)H-Index: 3
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Abstract Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) share certain physicochemical parameters such as amphipathicity, hydrophobicity, cationicity and pI, due to which these two groups of peptides also exhibit overlapping functional characteristics. In our current work, we have evaluated antimicrobial properties of cell-penetrating peptides derived from Latarcin1. Latarcin derived peptide (LDP) exhibited antimicrobial activity against representative microorganisms tested an...
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#1Bi He (SCUT: South China University of Technology)H-Index: 1
#2Shiyi Ma (SCUT: South China University of Technology)H-Index: 1
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Abstract The increasing emergence of drug resistant pathogenic bacteria poses a great challenge to clinical therapy and a threat to public health. Cationic peptides have received great attention for their unique antibacterial mechanism and ability to combat drug-resistant bacteria. In this study, we designed a TAT-modified cationic peptide PA-28 which self-assembled into nanoparticles of about 150 nm. These nanoparticles showed strong antimicrobial activities against both gram-positive and gram-...
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#1Samad Mussa Farkhani (Tabriz University of Medical Sciences)H-Index: 8
#2Abbas Asoudeh Fard (Tabriz University of Medical Sciences)H-Index: 1
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Recently, silver nanoparticles (AgNPs) have been used for cancer treatment. To achieve a successful anticancer activity, AgNP needs to be delivered sufficiently to the cells. Cell-penetrating peptides (CPPs) are small cationic peptides that have ability to transport various cargos across cell membranes. In this study, a strategy was developed for cancer treatment, where AgNP modified with CPPs displayed dramatically antitumor activity in MCF-7 cell lines. Peptides-modified AgNPs showed significa...
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Paclitaxel (PTX) and organophilic iron oxide nanocrystals of 7 nm average size were co-encapsulated in the oily core of poly(lactide)-poly(ethyleneglycol) (PLA-PEG) nanocapsules in order to develop magnetically responsive nanocarriers of PTX. The nanocapsules were prepared by a solvent displacement technique and exhibited satisfactory drug and iron oxide loading efficiency, high colloidal stability, and sustained drug release properties. Drug release also proved responsive to an alternating magn...
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#1Manzar Abbas (CAS: Chinese Academy of Sciences)H-Index: 5
#2Qianli Zou (CAS: Chinese Academy of Sciences)H-Index: 16
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Tremendous interest in self-assembly of peptides and proteins towards functional nanomaterials has been inspired by naturally evolving self-assembly in biological construction of multiple and sophisticated protein architectures in organisms. Self-assembled peptide and protein nanoarchitectures are excellent promising candidates for facilitating biomedical applications due to their advantages of structural, mechanical, and functional diversity and high biocompability and biodegradability. Here, t...
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#1Mehri Niazi (Tabriz University of Medical Sciences)H-Index: 2
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ABSTRACTIntroduction: The discussion about cancer treatment has a long history. Chemotherapy, one of the promising approaches in cancer therapy, is limited in the clinic as plenty of factors evolve and prevent appropriate therapeutic response to drugs. Multi-drug resistance (MDR), which is mostly P-glycoprotein-mediated, is described as the most well-known impediment in this contribution. It extrudes several agents out of cells, arising MDR and decreasing the bioavailability of drugs. Hence, can...
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