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Ali Shirani
Tabriz University of Medical Sciences
CytotoxicityCell-penetrating peptideDrug deliveryToxicityBiochemistry
5Publications
3H-index
17Citations
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Publications 6
Newest
#2Ali Shirani (Tabriz University of Medical Sciences)H-Index: 3
#3Ali Nokhodchi (University of Sussex)H-Index: 43
Last. Hadi Valizadeh (Tabriz University of Medical Sciences)H-Index: 29
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The low cellular uptake of Methotrexate (MTX), a commonly used anticancer drug, is a big challenge for efficient cancer therapy. Self-assembled peptide nanoparticles (SAPNs) are one of the ...
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#1Samaneh Mohammadi (Tabriz University of Medical Sciences)H-Index: 3
#2Hadi Valizadeh (Tabriz University of Medical Sciences)H-Index: 29
Last. Ali Nokhodchi (University of Sussex)H-Index: 43
view all 8 authors...
AbstractA new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the antitumor activity of epirubicin (EPR). Various amphiphilic CPPs were synthesized by solid phase peptide synthesis method and were chemically conjugated to EPR. Their corresponding nanoparticles (CPPs-E4 and CPPs-E8) were prepared via non-covalent binding of the peptides and polyanions. Cytotoxicity and anti-proliferative activity were evaluated by MTT assay. ...
3 CitationsSource
#1Hadi ValizadehH-Index: 29
Last. Jafar AkbariH-Index: 4
view all 7 authors...
4 CitationsSource
#1Samad Mussa Farkhani (Tabriz University of Medical Sciences)H-Index: 8
#2Ali Shirani (Tabriz University of Medical Sciences)H-Index: 3
Last. Hadi Valizadeh (Tabriz University of Medical Sciences)H-Index: 29
view all 6 authors...
Cell penetrating peptides (CPPs) were developed as vehicles for efficient delivery of various molecules. An ideal CPP-peptide should not display any toxicity against cancer cells as well as healthy cells and efficiently enter into the cell. Because of the cationic nature and the intrinsic vector capabilities, these peptides can cause cytotoxicity. One of the possible reasons for toxicity of CPPs is direct translocation and consequently, pore formation on the plasma membrane. In this study it was...
4 CitationsSource
#1Ali Shirani (Tabriz University of Medical Sciences)H-Index: 3
Last. Hadi Valizadeh (Tabriz University of Medical Sciences)H-Index: 29
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Purpose: Cell-penetrating peptides (CPPs) are used for delivering drugs and other macromolecular cargo into living cells. In this paper, we investigated the relationship between the structural/physicochemical properties of four new synthetic peptides containing arginine-tryptophan in terms of their cell membrane penetration efficiency. Methods: The peptides were prepared using solid phase synthesis procedure using FMOC protected amino acids. Fluorescence-activated cell sorting and fluorescence im...
1 CitationsSource
#1Samaneh Mohammadi (Tabriz University of Medical Sciences)H-Index: 3
Last. Hadi Valizadeh (Tabriz University of Medical Sciences)H-Index: 29
view all 7 authors...
Purpose: Breast cancer is the second leading cancer type among people of advanced countries. Various methods have been used for cancer treatment such as chemotherapy and radiotherapy. In the present study we have designed and synthesized a new group of drug delivery systems (DDS) containing a new class of Cell Penetrating Peptides (CPPs) named Peptide Amphiphiles (PAs). Methods: Two PAs and anionic peptides were synthesized using solid phase peptide synthesis (SPPS), namely [KW]4, [KW]5, E4 and ...
5 CitationsSource
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