Original paper
Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience
Abstract
GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinical phenotype, or disease progression in 160 GRN carriers. Importantly, progranulin levels were influenced by gender, with lower...
Paper Details
Title
Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience
Published Date
Jul 1, 2020
Journal
Volume
91
Pages
167.e1 - 167.e9
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Notes
History