Original paper

Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion

Volume: 477, Issue: 5, Pages: 937 - 951
Published: Mar 6, 2020
Abstract
The cisplatin-1,2-d(GpG) (Pt-GG) intrastrand cross-link is the predominant DNA lesion generated by cisplatin. Cisplatin has been shown to predominantly induce G to T mutations and Pt-GG permits significant misincorporation of dATP by human DNA polymerase β (polβ). In agreement, polβ overexpression, which is frequently observed in cancer cells, is linked to cisplatin resistance and a mutator phenotype. However, the structural basis for the...
Paper Details
Title
Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion
Published Date
Mar 6, 2020
Volume
477
Issue
5
Pages
937 - 951
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