Original paper
A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
Abstract
The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model, we demonstrate that Mre11 suppresses proliferation and DNA damage induced by diverse oncogenic drivers through a p53-independent mechanism. Breast...
Paper Details
Title
A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
Published Date
Feb 1, 2020
Journal
Volume
30
Issue
5
Pages
1385 - 1399.e7
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Notes
History