Alternative Splicing of Cav1.2 in ARVC Patients

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare hereditary disease comprising various mutations of desmosomal proteins. The first overt symptoms are often severe arrhythmias such as sudden cardiac death (SCD). We found alterations in sodium currents and Ca cycling but the exact molecular mechanisms leading to arrhythmias are still not fully understood. We generated induced pluripotent stem cells from an ARVC patient after...