Probing the Effects of Calmodulinopathy Mutations on Cav2.1 Channels

Calmodulin (CaM) forms a key component of the cellular response to calcium influx in a number of excitable cell types. In both neuronal and cardiac cells, CaM serves as the calcium sensor for multiple voltage gated calcium channels, modulating ion channel activity via robust feedback mechanisms. Such is the case for the Cav2.1 channel, a critical component of the neurotransmitter exocytosis machinery. In these channels, CaM has a well-described...