Changes in Number and Structure of Nerve Receptors (AMPARs) Associated with Memory in Dissociated Hippocampal Neurons

Changes in the number and structure of GluA1- and GluA2-type AMPA receptors (AMPAR) are important for long-term potentiation (LTP), in which synaptic strength increases and leads to learning. Electrophysiology, the standard method, is insufficient to quantify those changes because it measures the product of the current per receptor and the number of receptors. Here we used super-resolution fluorescence to quantify the change in the number of...