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Paul R. Selvin
University of Illinois at Urbana–Champaign
290Publications
53H-index
12.6kCitations
Publications 281
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#1Marco Tjioe (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
#2Saurabh Shukla (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last.Paul R. Selvin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 53
view all 8 authors...
How cargoes move within a crowded cell, over long distances and at speeds nearly the same as when moving on unimpeded pathway, has long been mysterious. Through an in vitro forcegliding assay, which involves measuring nanometer displacement and piconewtons of force, we show that kinesins (from 2 to 8) communicate in a team by inducing tension (up to 4 pN) on the cargo. Kinesins adopt two distinct states, with one-third slowing down the microtubule and twothirds speeding it up. Resisting kinesins...
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#1Giorgio Tortarolo (IIT: Istituto Italiano di Tecnologia)H-Index: 4
#2Yuansheng SunH-Index: 2
Last.Giuseppe Vicidomini (IIT: Istituto Italiano di Tecnologia)H-Index: 25
view all 10 authors...
Stimulated emission depletion (STED) microscopy is a powerful super-resolution microscopy technique that enables observation of macromolecular complexes and sub-cellular structures with spatial resolution well below the diffraction limit. However, resolution in the double-digit nanometer range can be obtained only using high intensity depletion laser, at the cost of increased photo-damage, which significantly limits STED applications in live specimens. To minimize this, we use the separation by ...
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#1Marco Tjioe (Indiana Biosciences Research Institute)H-Index: 1
#2Saurabh Shukla (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last.Paul R. Selvin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 53
view all 8 authors...
How cargoes move within a crowded cell, over long distances and at speeds that are nearly the same as when moving on an unimpeded pathway, has long been mysterious. Through an in vitro gliding assay, which involves measuring nanometer displacement and piconewtons of force, we have evidence that when kinesins, a cytoplasmic molecular motor, operate in small groups, from 2 to 10, they can communicate among themselves through an asymmetric tug-of-war by inducing tension (up to 4 pN) on the cargo. S...
2 CitationsSource
#1Janet SheungH-Index: 3
#2Pinghua GeH-Index: 13
Last.Paul R. SelvinH-Index: 53
view all 6 authors...
Source
#1Giorgio Tortarolo (IIT: Istituto Italiano di Tecnologia)H-Index: 4
#2Yuansheng SunH-Index: 2
Last.Giuseppe Vicidomini (IIT: Istituto Italiano di Tecnologia)H-Index: 25
view all 9 authors...
Stimulated emission depletion microscopy (STED) is one of the pivotal super-resolution techniques. It overcomes the spatial resolution limit imposed by the diffraction by using an additional laser beam, the STED beam, intensity of which is directly related to the achievable resolution. Despite reaching nanometer resolution, much effort in recent years has been devoted to reducing the STED beam intensity because it may lead to photo-damaging effects. Accessing the spatial information encoded in t...
2 CitationsSource
#1Giorgio Tortarolo (IIT: Istituto Italiano di Tecnologia)H-Index: 4
#2Yuansheng SunH-Index: 2
Last.Giuseppe Vicidomini (IIT: Istituto Italiano di Tecnologia)H-Index: 25
view all 9 authors...
Stimulated emission depletion microscopy (STED) is one of the pivotal super-resolution techniques. It overcomes the spatial resolution limit imposed by the diffraction by using an additional laser beam, the STED beam, whose intensity is directly related to the achievable resolution. Despite achieving nanometer resolution, much effort in recent years has been devoted to reduce the STED beam intensity because it may lead to photo-damaging effects. Exploring the temporal dynamics of the detected fl...
Source
#1Janet Sheung (Vassar College)H-Index: 3
#2Pinghua Ge (UIUC: University of Illinois at Urbana–Champaign)H-Index: 13
Last.Paul R. Selvin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 53
view all 6 authors...
Quantum dots are fluorescent nanoparticles with narrow-band, size-tunable, and long-lasting emission. Typical formulations used for imaging proteins in cells are hydrodynamically much larger than the protein targets, so it is critical to assess the impact of steric effects deriving from hydrodynamic size. This report analyzes a new class of quantum dots that have been engineered for minimized size specifically for imaging receptors in narrow synaptic junctions between neurons. We use fluorescenc...
3 CitationsSource
#1Kai Wen Teng (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
#2Pin Ren (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last.Paul R. Selvin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 53
view all 3 authors...
1 CitationsSource
#1Jary Y. Delgado (U of C: University of Chicago)H-Index: 2
#2Paul R. Selvin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 53
Calcium dynamics in presynaptic terminals regulate the response dynamics of most central excitatory synapses. However, this dogma has been challenged by the hypothesis that mobility of the postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid subtype glutamate receptors (AMPAR) plays a role in tuning fast excitatory synaptic transmission. In this review, we re-evaluate the factors regulating postsynaptic AMPAR mobility, reassess the modeling parameters, analyze the experimental t...
2 CitationsSource
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