Spectral Analysis of a Fast Biomolecular Transition in Magnetic Tweezers Measurements

Dynamic structural changes in biomolecules such as proteins and DNA are crucial for their correct function. These processes often involve transient intermediate states that occur on the (sub-)millisecond timescale. The investigation of such fast dynamics is experimentally challenging in particular in single molecule measurements. Here we investigate the limited branch migration of a Holliday junction within the torsionally constraint DNA of a...