Low Serum Insulinlike Growth Factor II Levels Correlate with High BMI in American Indian Adults

Objective Insulinlike growth factor II (IGF‐II) regulates metabolism and growth. In humans, both positive and negative relationships have been reported between serum IGF‐II levels and obesity. This study assessed the relationship between serum IGF‐II levels and BMI and determined whether IGF‐II levels predict weight gain. Methods Serum samples were available from 911 American Indians with a recorded BMI. IGF‐II was measured using enzyme‐linked...