Robert L. Hanson
National Institutes of Health
EndocrinologyType 2 diabetesPopulationDiabetes mellitusMedicine
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Publications 321
#1Hye In Kim (Regeneron)
#2Nehal Gosalia (Regeneron)H-Index: 4
Last. Clifton Bogardus (NIH: National Institutes of Health)H-Index: 75
view all 11 authors...
Applying whole exome sequencing (WES) to populations with unique genetic architecture has the potential to reveal novel genes and variants associated with traits and diseases. We sequenced and analyzed the exomes of 6,716 individuals from an American Indian population in Southwest US (Southwestern American Indian, or SWAI) with well-characterized metabolic traits. We found that individuals of SWAI have distinct allelic architecture compared to individuals with European and East Asian ancestry, w...
#1Yunhua L. Muller (NIH: National Institutes of Health)H-Index: 15
#2Robert L. Hanson (NIH: National Institutes of Health)H-Index: 72
Last. Leslie J. Baier (NIH: National Institutes of Health)H-Index: 36
view all 9 authors...
OBJECTIVE: Insulinlike growth factor II (IGF-II) regulates metabolism and growth. In humans, both positive and negative relationships have been reported between serum IGF-II levels and obesity. This study assessed the relationship between serum IGF-II levels and BMI and determined whether IGF-II levels predict weight gain. METHODS: Serum samples were available from 911 American Indians with a recorded BMI. IGF-II was measured using enzyme-linked immunosorbent assay. RESULTS: Serum IGF-II levels ...
#1Robert C. Williams (NIH: National Institutes of Health)H-Index: 1
#2William C. Knowler (NIH: National Institutes of Health)H-Index: 90
Last. Leslie J. Baier (NIH: National Institutes of Health)H-Index: 36
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Abstract The Pima Indians of the Gila River Indian Community in Arizona have participated in a long-range study of type 2 diabetes mellitus since 1965 and have been the subject of HLA typing and population studies since the early days of serological assays. These data have been in numerous HLA workshops and conferences and have been the source of at least five novel alleles at the classical HLA loci. In recent time nearly the entire study group was subject to next generation sequencing by whole ...
1 CitationsSource
#1Lisa R. Staimez (Emory University)H-Index: 7
#2Mohan DeepaH-Index: 39
Last. K.M. Venkat Narayan (Emory University)H-Index: 58
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#1E. Jennifer Weil (Emory University)H-Index: 1
#2Sayuko KobesH-Index: 28
Last. Robert L. Hanson (NIH: National Institutes of Health)H-Index: 72
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In type 2 diabetes (T2DM), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) systematically underestimates the measured adjusted glomerular filtration rate (aGFR) when aGFR is high. We studied the extent to which glycemic variables associate with kidney function, and developed equations including these variables that estimate aGFR in people with T2DM. Diabetic Pima people had aGFR measured from iothalamate clearance divided b...
#1Sherita Hill Golden (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 47
Last. William C. Knowler (NIH: National Institutes of Health)H-Index: 90
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Type 2 diabetes is a common disease worldwide, but its prevalence varies widely by geographical region and by race/ethnicity. This review summarises differences in the frequencies of type 2 diabetes according to race, ethnicity, socioeconomic position, area of residence and environmental toxins. Type 2 diabetes susceptibility often begins early in life, starting with genetic susceptibility at conception and continuing in later life, via in utero, childhood and adult exposures. Early-life factors...
#1Robert L. Hanson (NIH: National Institutes of Health)H-Index: 72
#2Saied SafabakhshH-Index: 1
Last. Robert G. Nelson (NIH: National Institutes of Health)H-Index: 64
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Aims/hypothesis Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most other global populations. The aim of the present study was to assess the association of CREBRF variants with obesity and diabetes in Pacific Islander (largely Marianas and Micronesian) populations from Guam and Saipan.
1 CitationsSource
#1Caroline Gluck (UPenn: University of Pennsylvania)H-Index: 3
#2Chengxiang Qiu (UPenn: University of Pennsylvania)H-Index: 15
Last. Katalin Susztak (UPenn: University of Pennsylvania)H-Index: 38
view all 18 authors...
Epigenetic changes might provide the biological explanation for the long-lasting impact of metabolic alterations of diabetic kidney disease development. Here we examined cytosine methylation of human kidney tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes and varying degrees of kidney disease using a cross-sectional design. We identify cytosine methylation changes associated with kidney structural damage and build a model for kidney function decline. We fin...
1 CitationsSource
#1K.M. Venkat NarayanH-Index: 58
#2Dimple KondalH-Index: 15
Last. Nikhil TandonH-Index: 44
view all 17 authors...
#1K.M. Venkat NarayanH-Index: 58
#2Dimple KondalH-Index: 15
Last. Nikhil TandonH-Index: 44
view all 17 authors...