Clonal origin in normal adults of all blood lineages and circulating hematopoietic stem cells
Abstract
•Lineage tracing of somatically acquired DNA transversions enables a sensitive method for tracking hematopoietic clones. •This approach has revealed multilineage clones persisting in two normal individuals up to 53 years of age. Characterization of human cells that sustain blood cell production lifelong has historically been inferred from phenotypically defined subsets of cells assayed in vitro, in transplanted immunodeficient mice, or in...
Paper Details
Title
Clonal origin in normal adults of all blood lineages and circulating hematopoietic stem cells
Published Date
Mar 1, 2020
Journal
Volume
83
Pages
25 - 34.e2
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Notes
History