Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation

•Histone acetyltransferase Kat6b is highly expressed in hematopoietic stem cells•KAT6B expression is reduced in hematopoietic stem cells with aging•Reduced Kat6b causes decreased erythropoietic activity and increased myeloid differentiation Aged hematopoietic stem cells (HSCs) undergo biased lineage priming and differentiation toward production of myeloid cells. A comprehensive understanding of gene regulatory mechanisms causing HSC aging is...