Original paper
Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation
Abstract
Pyruvate kinase M2 (PKM2) links metabolic and inflammatory dysfunction in atherosclerotic coronary artery disease; however, its role in oxidized LDL (Ox-LDL)-induced macrophage foam cell formation and inflammation is unknown and therefore was studied. In recombinant mouse granulocyte-macrophage colony-stimulating factor-differentiated murine bone marrow-derived macrophages, early (1–6 h) Ox-LDL treatment induced PKM2 tyrosine 105 phosphorylation...
Paper Details
Title
Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation
Published Date
Mar 1, 2020
Journal
Volume
61
Issue
3
Pages
351 - 364
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Notes
History