Journal of Lipid Research
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#1Daisuke Yamamuro (Jichi Medical University)H-Index: 3
#2Hisataka Yamazaki (Jichi Medical University)H-Index: 2
Last. Adriaan G. HolleboomH-Index: 19
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The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in 206 healthy volunteers and 8 individuals with genetic LCAT deficiency, including familial LCAT deficiency (FLD) and fish eye disease (FED). In the healthy volunteers, the mean values of the ester-to-total molar ratios of the following sterols varied...
#1Douglas Borchman (University of Louisville)H-Index: 36
Lens and tear film lipids are as unique as the systems they reside in. The major lipid of the human lens is dihydrosphingomylein, found in quantity only in the lens. The lens contains a cholesterol to phospholipid molar ratio as high as 10:1, more than anywhere in the body. Lens lipids contribute to maintaining lens clarity, and alterations in lens lipid composition due to age are likely to contribute to cataract. Lens lipid composition reflects adaptations to the unique characteristics of the l...
#1Raju V. S. Rajala (OU: University of Oklahoma)H-Index: 23
The field of phosphoinositide signaling has expanded significantly in recent years. Phosphoinositides (PIs) are universal signaling molecules that directly interact with membrane proteins or with cytosolic proteins containing domains that directly bind phosphoinositides and are recruited to cell membranes. Through the activities of PI kinases and PI phosphatases, seven distinct phosphoinositide lipid molecules are formed from the parent molecule phosphatidylinositol. PI signals regulate a wide r...
#1Joanna M. Kwiatek (RU: Rutgers University)
#2George M. Carman (RU: Rutgers University)H-Index: 57
Phosphatidic acid (PA) phosphatase, encoded by PAH1 in the yeast Saccharomyces cerevisiae, catalyzes the Mg2+-dependent dephosphorylation of PA, producing diacylglycerol at the nuclear/endoplasmic reticulum (ER) membrane. This enzyme plays a major role in triacylglycerol synthesis and in the regulation of phospholipid synthesis. As an interfacial enzyme, PA phosphatase interacts with the membrane surface, binds its substrate, and catalyzes its reaction. The Triton X-100/PA-mixed micellar system ...
#1Manisha Ray (DI: Discovery Institute)H-Index: 1
#2Kazufumi Nagai (DI: Discovery Institute)
Last. Jerold Chun (DI: Discovery Institute)H-Index: 94
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Native interactions between lysophospholipids (LPs) and their cognate LP receptors are difficult to measure because of lipophilicity and/or the adhesive properties of lipids, which contribute to high levels of non-specific binding in cell membrane preparations. Here, we report development of a free solution assay (FSA) where label-free LPs bind to their cognate G protein-coupled receptors (GPCRs), coupled with a recently reported compensated interferometric reader (CIR) to quantify native bindin...
#1Elliot H. Choi (Case Western Reserve University)H-Index: 2
#2Anahita Daruwalla (University of California, Berkeley)
Last. Krzysztof Palczewski (UCI: University of California, Irvine)H-Index: 101
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Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration. This photochemical reaction initiates the signal transduction pathway that eventually leads to the transmission of a visual signal to the brain and leaves the opsins insensitive to further light stimulation. For the eye to restore light sensitivity, opsins require recharging with 11-cis-retinal. This trans-cis back conversion is achieved through a ser...
#1Takeshi Harayama (University of Geneva)H-Index: 8
#2Takao ShimizuH-Index: 82
Polyunsaturated fatty acids (PUFAs), such as arachidonic acid and docosahexaenoic acid, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling lipids, for which knowledge about synthetic pathways and receptors has accumulated. However, due to their extreme diversity and the ambiguity concerning the identity of their cognate receptors, the roles of PUFA-derived signaling lipids requi...
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