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Journal of Lipid Research
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#1Yipeng Sui (UK: University of Kentucky)H-Index: 12
#2Zhaojie Meng (UCR: University of California, Riverside)
Last. Changcheng Zhou (UCR: University of California, Riverside)
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The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many genes involved in xenobiotic metabolism. We have previously reported that PXR has pro-atherogenic effects in animal models, but how PXR in different tissues or cell types contributes to atherosclerosis development remain elusive. In this study, ...
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#1Hyo-Jung Kim (SNU: Seoul National University)H-Index: 20
#2Bong-Jin Lee (SNU: Seoul National University)H-Index: 23
Last. Ae-Ran Kwon (Daegu Haany University)H-Index: 4
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Acne is one of the most common dermatological conditions, but the details of its pathology are unclear, and current management regimens often have adverse effects. Cutibacterium acnes is known as a major acne-associated bacterium that derives energy from lipase-mediated sebum lipid degradation. C. acnes is commensal, but lipase activity has been observed to differ among C. acnes types. For example, higher populations of the type IA strains are present in acne lesions with higher lipase activity....
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#1Inga Nilsson (Novartis)H-Index: 2
#2Sheng Y Lee (Novartis)
Last. David A. Six (Novartis)H-Index: 4
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Gram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPS) on the outer leaflet and phospholipids (PLs) on the inner leaflet. Loss of this asymmetry due to mutations in the lipopolysaccharide (LPS) biosynthesis or transport pathways causes externalization of PLs to the outer leaflet of the OM and leads to OM permeability defects. Here, we employed metabolic labeling to detect a compromised OM in intact bacteria. Phosphatidylcholine synthase (...
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#1Eyad Naser (University of Duisburg-Essen)
#2Stephanie Kadow (University of Duisburg-Essen)H-Index: 4
Last. Katrin Anne Becker (University of Duisburg-Essen)H-Index: 22
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Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently characterized. Here, we found that 1-aminodecylidene bis-phosphonic acid (ARC39) specifically and efficiently (>90%) inhibits both lysosomal and secretory ASM in vitro. Results from investigating sphingomye...
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#1Stephen G. Young (UCLA: University of California, Los Angeles)H-Index: 85
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#1Ilya Levental (University of Texas at Austin)H-Index: 31
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#2Helen H. Wang (Albert Einstein College of Medicine)H-Index: 2
Last. Christopher Kent ArnattH-Index: 1
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Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones as men, and oral contraceptives and other estrogen therapies dramatically increase that risk. Further animal studies revealed that estrogen promotes cholesterol gallstone formation through the estrogen receptor alpha (ERalpha), but not ERbeta, pathway. More importantly, some genetic and pathophysiological studies found that the G protein-coupled estr...
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Plasma lipoprotein (a) [Lp(a)] levels are largely determined by variation in the LPA gene, which codes for apo(a). Genome-wide association studies (GWASs) have identified nonsynonymous variants in LPA that associate with low Lp(a) levels, although their effect on apo(a) function is unknown. We investigated two such variants, R990Q and R1771C, which were present in four null Lp(a) individuals, for structural and functional effects. Sequence alignments showed the R990 and R1771 residues to be high...
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Endocrinology
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