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Manoj Kumar Barthwal
Council of Scientific and Industrial Research
95Publications
21H-index
1,479Citations
Publications 95
Newest
#1Abrar A. Khan (Indian Institute of Technology Madras)H-Index: 3
#2Heena Agarwal (Central Drug Research Institute)H-Index: 1
Last.Nitish R. Mahapatra (Indian Institute of Technology Madras)H-Index: 21
view all 0 authors...
Hypercholesterolemia is a strong predictor of cardiovascular diseases. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase gene (Hmgcr) coding for the rate-limiting enzyme in the cholesterol biosynthesis pathway is a crucial regulator of plasma cholesterol levels. However, the post-transcriptional regulation of Hmgcr remains poorly understood. The main objective of this study was to explore the role of miRNAs in the regulation of Hmgcr expression. Systematic in silico predictions and experimental an...
#1Ankita Singh (Central Drug Research Institute)H-Index: 7
#2Vishal Singh (Central Drug Research Institute)H-Index: 16
Last.Manoj Kumar Barthwal (Central Drug Research Institute)H-Index: 21
view all 7 authors...
#1Santosh Reddy (CSIR: Council of Scientific and Industrial Research)
#2Heena Agarwal (CSIR: Council of Scientific and Industrial Research)
Last.Manoj Kumar Barthwal (CSIR: Council of Scientific and Industrial Research)H-Index: 21
view all 4 authors...
#1Samreen Sadaf (Central Drug Research Institute)
#2Abhishek Singh (Central Drug Research Institute)H-Index: 9
Last.Madhu Dikshit (Central Drug Research Institute)H-Index: 33
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#1Anant Kumar Jaiswal (CSIR: Council of Scientific and Industrial Research)H-Index: 1
#2Sukka Santosh Reddy (AcSIR: Academy of Scientific and Innovative Research)H-Index: 1
Last.Manoj Kumar Barthwal (CSIR: Council of Scientific and Industrial Research)H-Index: 21
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In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes. Phenotype-switching experiments established an association between upregulated miR-99a expression and the M2 phenotype. Overexpression of miR-99a prevented M1 phenoty...
#1Abrar A. Khan (Indian Institute of Technology Madras)H-Index: 3
#2Poovitha Sundar (Indian Institute of Technology Madras)
Last.Nitish R. Mahapatra (Indian Institute of Technology Madras)H-Index: 21
view all 8 authors...
3-Hydroxy-3-methyl glutaryl-coenzyme A reductase (Hmgcr) encoding the rate-limiting enzyme in the cholesterol biosynthesis pathway is a candidate gene for essential hypertension (EH). However, the regulation of Hmgcr in rat models of hypertension (viz. Spontaneously Hypertensive Rats [SHR] and its normotensive control Wistar/Kyoto [WKY] strain) is unknown. Here, we show that Hmgcr transcript and protein levels are diminished in liver tissues of SHR as compared to WKY. Consistently, a number of o...
#1Vikas Arige (Indian Institute of Technology Madras)H-Index: 1
#2Anshu Agarwal (Indian Institute of Technology Madras)
Last.Nitish R. Mahapatra (Indian Institute of Technology Madras)H-Index: 21
view all 9 authors...
Abstract Monoamine oxidase B (MAO-B), a flavoenzyme located in the outer mitochondrial membrane, is involved in the catabolism of monoamines. Altered levels of MAO-B are associated with cardiovascular/neuronal diseases. However, molecular mechanisms of MAO-B gene regulation are partially understood. We undertook a systematic analysis of the MAO-B gene to identify the key transcriptional/post-transcriptional regulatory molecules. Expression of MAO-B promoter–reporter constructs in cultured cells ...
#1Abrar A. Khan (Indian Institute of Technology Madras)H-Index: 3
#2Heena Agarwal (Central Drug Research Institute)H-Index: 1
Last.Nitish R. Mahapatra (Indian Institute of Technology Madras)H-Index: 21
view all 0 authors...
Hypercholesterolemia is a strong predictor of cardiovascular diseases that result in the largest number of mortality and morbidity worldwide. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase gene (Hmgcr) coding for the rate-limiting enzyme in the cholesterol biosynthesis pathway is a crucial regulator of plasma cholesterol levels. However, the post-transcriptional regulation of Hmgcr remains poorly understood. Here, we show that Hmgcr is markedly inhibited, while miR-27a is highly induced in vari...
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