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Estimation of GFR in Patients With Cystic Fibrosis: A Cross-Sectional Study:

Published on Jan 15, 2020in Canadian journal of kidney health and disease
路 DOI :10.1177/2054358119899312
Andrea Wallace (UWO: University of Western Ontario), April Price2
Estimated H-index: 2
(UWO: University of Western Ontario)
+ 2 AuthorsGuido Filler44
Estimated H-index: 44
Abstract
Background:Patients with cystic fibrosis (CF) have frequent infectious complications requiring nephrotoxic medications, necessitating monitoring of renal function. Although adult studies have sugge...
  • References (33)
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References33
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#1Alexia J. Murphy (UQ: University of Queensland)H-Index: 12
#2Rebecca J. Hill (UQ: University of Queensland)H-Index: 15
Last. Peter Davies (UQ: University of Queensland)H-Index: 92
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Summary Background & aims Nutritional status is an important consideration in many pediatric clinical conditions. This paper aimed to examine and compare the nutritional status, represented by body cell mass (BCM), of children with cancer, Crohn's disease (CD), cystic fibrosis (CF) and anorexia nervosa (AN). Methods Anthropometry was measured and BCM was calculated from whole body potassium-40 counting in 259 children being treated for clinical conditions (n聽=聽66 cancer; n聽=聽59 AN; n聽=聽75 CF; n聽...
7 CitationsSource
#1Dov A DegenH-Index: 1
#2Jyotsna JanardanH-Index: 2
Last. Rowan G. WalkerH-Index: 41
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Abstract Background There has been limited examination of the performance of glomerular filtration rate estimation (eGFR) equations in lung transplant populations. This study aimed to compare the performance of serum creatinine and cystatin C based eGFR equations with Tc-99m diethylenetriaminepentaacetic acid (DTPA) GFR measurements in individuals with end-stage lung disease, either prior to, or following, lung transplantation. Methods In this prospective observational study, participants underw...
2 CitationsSource
#1Ola Z. Ismail (UWO: University of Western Ontario)H-Index: 3
#2Vipin Bhayana (UWO: University of Western Ontario)H-Index: 7
Last. Guido Filler (UWO: University of Western Ontario)H-Index: 44
view all 6 authors...
2 CitationsSource
#1Lesley A. Inker (Tufts University)H-Index: 37
#2Hocine Tighiouart (Tufts University)H-Index: 47
Last. Andrew S. Levey (Tufts University)H-Index: 129
view all 17 authors...
Background 尾-Trace protein (BTP) and 尾 2 -microglobulin (B2M) are novel glomerular filtration markers that have stronger associations with adverse outcomes than creatinine. Comparisons of BTP and B2M to creatinine and cystatin C are limited by the absence of rigorously developed glomerular filtration rate (GFR) estimating equations for the novel markers. Study Design Study of diagnostic test accuracy. Setting & Participants Pooled database of 3 populations with chronic kidney disease (CKD) with ...
51 CitationsSource
#1Samantha H. Witzel (London Health Sciences Centre)H-Index: 2
#2Shih-Han S. Huang (London Health Sciences Centre)H-Index: 10
Last. Guido Filler (UWO: University of Western Ontario)H-Index: 44
view all 4 authors...
Background and objectives Sex may affect the performance of small molecular weight proteins as markers of GFR because of differences in fat mass between the two sexes. The hypothesis was that the diagnostic performance of 尾 -trace protein, a novel marker of GFR, would be significantly better in boys than in girls. Design, setting, participants, & measurements GFR, height, weight, serum creatinine, and 尾 -trace protein were measured in 755 children and adolescents (331 girls) undergoing 99 techne...
11 CitationsSource
#1Anders GrubbH-Index: 67
#2Masaru Horio (Osaka University)H-Index: 27
Last. C. A. FerreroH-Index: 6
view all 23 authors...
BACKGROUND: Many different cystatin C鈥揵ased equations exist for estimating glomerular filtration rate. Major reasons for this are the previous lack of an international cystatin C calibrator and the nonequivalence of results from different cystatin C assays. METHODS: Use of the recently introduced certified reference material, ERM-DA471/IFCC, and further work to achieve high agreement and equivalence of 7 commercially available cystatin C assays allowed a substantial decrease of the CV of the ass...
107 CitationsSource
#1Paraskevi Panagopoulou (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 16
#2Maria Fotoulaki (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 11
Last. Sanda Nousia-Arvanitakis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 18
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Background Optimal nutritional status (NS) in cystic fibrosis (CF) is associated with better lung function and increased overall survival. This study estimated the prevalence of malnutrition and obesity among CF patients in a tertiary center. Methods In a cross-sectional study of 68 CF patients (33 female; 37 children/adolescents) weight, height, body composition, respiratory function (% of the predicted forced expiratory volume in 1鈥塻; FEV1%pred) and serum lipids were measured; body mass index ...
26 CitationsSource
#1Mercedes de Onis (WHO: World Health Organization)H-Index: 54
#2Adelheid W. Onyango (WHO: World Health Organization)H-Index: 24
Last. Chessa K. LutterH-Index: 22
view all 6 authors...
Objective: To describe the worldwide implementation of the WHO Child Growth Standards (鈥榃HO standards鈥). Design: A questionnaire on the adoption of the WHO standards was sent to health authorities. The questions concerned anthropometric indicators adopted, newly introduced indicators, age range, use of sex-specific charts, previously used references, classification system, activities undertaken to roll out the standards and reasons for non-adoption. Setting: Worldwide. Subjects: Two hundred and ...
172 CitationsSource
#1George J. Schwartz (UR: University of Rochester)H-Index: 47
#2Michael F. Schneider (Johns Hopkins University)H-Index: 21
Last. Alvaro Munoz (Johns Hopkins University)H-Index: 80
view all 8 authors...
The Chronic Kidney Disease in Children study is a cohort of about 600 children with chronic kidney disease (CKD) in the United States and Canada. The independent variable for our observations was a measurement of glomerular filtration rate (GFR) by iohexol disappearance (iGFR) at the first two visits 1 year apart and during alternate years thereafter. In a previous report, we had developed GFR estimating equations utilizing serum creatinine, blood urea nitrogen, height, gender, and cystatin C me...
194 CitationsSource
#1Lesley A. Inker (Tufts University)H-Index: 37
#2Christian Schmidt (Tufts University)H-Index: 91
Last. Andrew S. Levey (Tufts University)H-Index: 129
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A b s t r ac t Background Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease. Cystatin C is an alternative filtration marker for estimating GFR. Methods Using cross-sectional analyses, we developed estimating equations based on cystatin C alone and in combination with creatinine in diverse populations totaling 5352 participants from 13 studies. These e...
1,478 CitationsSource
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