Targeting the Unfolded Protein Response in Hormone-Regulated Cancers

Recent studies established that hormonal pathways that are implicated in cancer regulate the UPR and provide survival benefits for cancer cells. Regulation of UPR has important phenotypic outcomes for breast and prostate cancer, both in the hormone-sensitive and hormone-therapy-resistant advanced stages. Among the UPR pathways, the inositol requiring enzyme (IRE)1 and protein kinase RNA-like ER kinase (PERK) arms are best studied and strongly...