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Yang Jin
Oslo University Hospital
CancerProstate cancerCancer researchBiochemistryBiology
28Publications
7H-index
222Citations
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Publications 32
Newest
#1Tingting Zhang (HUST: Huazhong University of Science and Technology)
#2Ningning Li (SYSU: Sun Yat-sen University)
Last. Xia Sheng (HUST: Huazhong University of Science and Technology)H-Index: 9
view all 5 authors...
The transcription factors of the MYC family play pivotal roles in the initiation and progression of human cancers. High oncogenic level of MYC invades low-affinity sites and enhancer sequences, which subsequently alters the transcriptome, causes metabolic imbalance, and induces stress response. The endoplasmic reticulum (ER) not only plays a central role in maintaining proteostasis, but also contributes to other key biological processes, including Ca(2+) metabolism and the synthesis of lipids an...
Source
#1Yang Jin (NMBU: Norwegian University of Life Sciences)H-Index: 7
#2Rolf Erik Olsen (NTNU: Norwegian University of Science and Technology)H-Index: 29
Last. Simen Rød Sandve (NMBU: Norwegian University of Life Sciences)H-Index: 16
view all 11 authors...
Domestication of animals imposes strong targeted selection for desired traits but can also result in unintended selection due to new domestic environments. Atlantic salmon was domesticated in the 1970s and has subsequently been selected for faster growth in systematic breeding programmes. More recently, salmon aquaculture has replaced fish oils (FO) with vegetable oils (VO) in feed, radically changing the levels of essential long-chain polyunsaturated fatty acids (LC-PUFA). Our aim was to study ...
1 CitationsSource
#1Yang Jin (University of Oslo)H-Index: 7
#2Fahri Saatcioglu (University of Oslo)H-Index: 30
Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One of these is the unfolded protein response (UPR), a highly conserved signaling pathway that is mounted in response to endoplasmic reticulum (ER) stress. Recent work showed that steroid hormones, in particular estrogens and androgens, regulate the canonical UPR pathways in breast cancer (BCa) and prostate cancer (PCa). In addition, UPR has pleiotropic effects in advanced disease and development of the...
1 CitationsSource
#1Yang Jin (NTNU: Norwegian University of Science and Technology)H-Index: 7
#2Rolf Erik Olsen (NTNU: Norwegian University of Science and Technology)H-Index: 29
Last. Yngvar Olsen (NTNU: Norwegian University of Science and Technology)H-Index: 47
view all 10 authors...
Domestication of Salmo salar has imposed strong selection for production traits since the 1970s. The domestication has also imposed a radical shift in diet. Whereas wild salmon eats invertebrates, crustaceans and fish, the dietary lipids in domestic feed has since 1990 gradually shifted from fish oil (FO) to vegetable oil (VO), causing a decrease intake of long-chain polyunsaturated fatty acids (LC-PUFA). We tested the hypothesis that this shift has induced domestication-specific features of lip...
1 CitationsSource
#1Nora Pällmann (University of Oslo)H-Index: 1
#2Marte Livgård (University of Oslo)H-Index: 1
Last. Fahri Saatcioglu (University of Oslo)H-Index: 30
view all 20 authors...
Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as well as disease states, including cancer. Since UPR can serve as a lever between survival and death, regulated control of its activity is critical for tumor formation and growth although the underlying mechanisms are poorly understood. Here we show that one of the main transcrip...
1 CitationsSource
#1Yu Wang (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Kai Wang (Wuhan Polytechnic University)H-Index: 1
Last. Xia Sheng (HUST: Huazhong University of Science and Technology)H-Index: 6
view all 4 authors...
Abstract The endoplasmic reticulum (ER) is the primary organelle responsible for the synthesis, modification, folding and secretion of proteins, especially in specialized secretory cells. It also contributes to the maintenance of cellular functions, such as Ca2+ storage, lipogenesis, gluconeogenesis, and organelle biogenesis. Cellular stress conditions, such as glucose deprivation, hypoxia and disturbance of Ca2+ homeostasis, may increase the risk of protein misfolding and perturb proteostasis. ...
1 CitationsSource
#1Yang Jin (NTNU: Norwegian University of Science and Technology)H-Index: 7
#2Rolf Erik Olsen (NTNU: Norwegian University of Science and Technology)H-Index: 29
Last. Yngvar Olsen (NTNU: Norwegian University of Science and Technology)H-Index: 5
view all 11 authors...
Abstract The onset of first feeding is a critical period for Atlantic salmon (Salmo salar). The fish goes through a dramatic transition, from using the yolk sac as an energy and nutrient resource to rely on exogenous food. However, the digestive system of salmon is not fully developed at start feeding. This is especially true for digestion and absorption of dietary lipids. To optimize lipid composition of the initial feed for better growth and development of salmon, it is important to have a sys...
Source
#1Ji-Hua Shi (Zhengzhou University)H-Index: 5
#2Wenzhi Guo (Zhengzhou University)H-Index: 7
Last. Shuijun Zhang (Zhengzhou University)H-Index: 10
view all 8 authors...
Source
#1Cheng Xu (KIZ: Kunming Institute of Zoology)
#2Yunfei Wang (KIZ: Kunming Institute of Zoology)
Last. Ren Lai (KIZ: Kunming Institute of Zoology)H-Index: 36
view all 10 authors...
Pancreatic cancer remains one of the deadliest human cancers despite current advances in conventional therapeutics including surgery and adjuvant therapies. Here, we showed that LZ1, a peptide derived from a snake venom cathelicidin, significantly inhibited growth of pancreatic cancer cells by inducing autophagy-dependent cell death both in vitro and in vivo. The LZ1-induced cell death was blocked by pharmacological or genetic inhibition of autophagy. In orthotopic model of pancreatic cancer, sy...
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#1Yang JinH-Index: 7
#2Inga Leena AngellH-Index: 3
Last. Knut RudiH-Index: 42
view all 6 authors...
1 CitationsSource
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