The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma
Abstract
In most cases, sorafenib-resistant HCC cells exhibit significant mesenchymal phenotype and stemness features. In this context, tumor cells might undergo cell fate transition in response to sorafenib or other targeted drugs in the presence or absence of genetic mutations. Therefore, understanding the major characteristics of drug-resistant cells state helps to discover new treatments that overcome drug resistance. To note, little is known about...
Paper Details
Title
The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma
Published Date
Jan 1, 2020
Journal
Volume
51
Pages
102610 - 102610
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