Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles

Glaucoma is a leading cause of severe visual impairment and blindness. Although high intraocular pressure (IOP) is an established risk factor for the disease, the role of abnormal ocular vessel function in the pathophysiology of glaucoma gains more and more attention. We tested the hypothesis that elevated intraocular pressure (IOP) causes vascular dysfunction in the retina.High IOP was induced in one group of mice by unilateral cauterization of...