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Adrian Gericke
University of Mainz
70Publications
12H-index
431Citations
Publications 72
Newest
#1Panagiotis Laspas (University of Mainz)H-Index: 4
#2Mayagozel B. Zhutdieva (University of Mainz)H-Index: 1
Last.Adrian Gericke (University of Mainz)H-Index: 12
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Muscarinic acetylcholine receptors have been implicated as potential neuroprotective targets for glaucoma. We tested the hypothesis that the lack of a single muscarinic receptor subtype leads to age-dependent neuron reduction in the retinal ganglion cell layer. Mice with targeted disruption of single muscarinic acetylcholine receptor subtype genes (M1 to M5) and wild-type controls were examined at two age categories, 5 and 15 months, respectively. We found no differences in intraocular pressure ...
1 CitationsSource
#1Joanna Wasielica-Poslednik (University of Mainz)H-Index: 5
#2Norbert Pfeiffer (University of Mainz)H-Index: 46
Last.Adrian Gericke (University of Mainz)H-Index: 12
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In this report, we present the results of a severe case of Sjogren’s syndrome-related keratopathy after fluocinolone acetonide 190-μg intravitreal implant (Iluvien®; Alimera Sciences Inc.) therapy. A 52-year-old Caucasian woman with Sjogren’s syndrome secondary to autoimmune hepatitis and primary sclerosing cholangitis was admitted to our emergency department owing to bilateral corneal ulcers and corneal perforation in the left eye following exposure keratopathy in an artificially induced coma. ...
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Objective. Atherogenic lipoproteins may impair vascular reactivity consecutively causing tissue damage in multiple organs via abnormal perfusion and excessive reactive oxygen species generation. We tested the hypothesis that chronic hypercholesterolemia causes endothelial dysfunction and cell loss in the retina. Methods. Twelve-month-old apolipoprotein E-deficient (ApoE-/-) mice and age-matched wild-type controls were used in this study ( per genotype for each experiment). Intraocular pressure, ...
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#1Verena Prokosch-Willing (University of Mainz)H-Index: 3
#2Karl Mercieca (University of Manchester)
Last.Adrian Gericke (University of Mainz)H-Index: 12
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Visual impairment and blindness are often caused by retinal ischemia-reperfusion (I/R) injury. We aimed to characterize a new model of I/R in pigs, in which the intraocular pathways were not manipulated by invasive methods on the ocular system. After 12 min of ischemia followed by 20 h of reperfusion, reactivity of retinal arterioles was measured in vitro by video microscopy. Dihydroethidium (DHE) staining, qPCR, immunohistochemistry, quantification of neurons in the retinal ganglion cell layer,...
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#1Jana C. Riedl (University of Mainz)H-Index: 1
#2Walter Lisch (University of Mainz)H-Index: 14
Last.Adrian Gericke (University of Mainz)H-Index: 12
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#1Joanna Wasielica-Poslednik (University of Mainz)H-Index: 5
#2Alexander K. Schuster (University of Mainz)H-Index: 10
Last.Adrian Gericke (University of Mainz)H-Index: 12
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Purpose. Incorrect anterior-posterior orientation of the Descemet endothelial complex (DEC) is one of the causes of failure of Descemet membrane endothelial keratoplasty (DMEK). We evaluated a new marking technique to avoid such a misorientation. Method. A new marking technique of the DEC was evaluated in patients requiring primary DMEK. A Braille-“R”-letter was applied dot by dot onto the stromal surface of the DEC after lifting it by injecting an air-bubble into the interface between the endot...
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#1Jenia Kouchek Zadeh (University of Mainz)H-Index: 1
#2Robert Ruemmler (University of Mainz)H-Index: 3
Last.Adrian Gericke (University of Mainz)H-Index: 12
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Abstract Acute respiratory distress syndrome (ARDS) is a clinical syndrome of acute lung failure in critically sick patients, which severely compromises the function of multiple organs, including the brain. Although, the optic nerve and the retina are a part of the central nervous system, the effects of ARDS on these ocular structures are completely unknown. Thus, the major goal of this study was to test the hypothesis that ARDS affects vascular function in the eye. ARDS was induced in anestheti...
1 CitationsSource
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#1Jana C. RiedlH-Index: 1
#2Adrian GerickeH-Index: 12
Last.Urs VossmerbaeumerH-Index: 3
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Selbstverletzendes Verhalten („nonsuicidal self-injury“, NNSI) ist ein haufiges Phanomen und tritt in Deutschland, v. a. in der Adoleszenz, mit einer Lebenszeitpravalenz von 25–35 % auf. Im Erwachsenenalter steht autoaggressives Verhalten meist im Zusammenhang mit psychischen Erkrankungen, wie z. B. – wie in den vorliegenden Fallen– im Rahmen einer Borderline-Personlichkeitsstorung. Verletzungen am Auge sind hierbei eher selten. Der behandelnde Arzt steht vor der Schwierigkeit, die Verletzung ri...
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