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Oxidative Medicine and Cellular Longevity
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4.87
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3640
Papers 3640
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#1Xiafang Wu (PRC: China Medical University (PRC))H-Index: 3
#2Ru Sun (PRC: China Medical University (PRC))H-Index: 1
Last.Yuanyuan Xu (PRC: China Medical University (PRC))H-Index: 16
view all 10 authors...
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#2Isabel Gronau (JU: Jacobs University Bremen)
Last.Rita DreierH-Index: 21
view all 4 authors...
Objective. The integrity of cartilage depends on the correct synthesis of extracellular matrix (ECM) components. In case of insufficient folding of proteins in the endoplasmic reticulum (ER) of chondrocytes, ECM proteins aggregate, ER stress evolves, and the unfolded protein response (UPR) is initiated. By this mechanism, chondrocytes relieve the stress condition or initiate cell death by apoptosis. Especially persistent ER stress has emerged as a pathogenic mechanism in cartilage diseases, such...
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The associations between milk intake frequency and milk fat consumption and telomere length, an index of biological aging, were studied using an NHANES sample of 5,834 U.S. adults and a cross-sectional design. The milk consumption variables were assessed with the NHANES Diet Behavior and Nutrition questionnaire. The quantitative polymerase chain reaction method was used to measure leukocyte telomere length. Results showed that milk consumption frequency was not related to telomere length; howeve...
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#1Elena Butturini (University of Verona)H-Index: 7
#2Alessandra Carcereri De Prati (University of Verona)H-Index: 19
Last.Sofia Mariotto (University of Verona)H-Index: 25
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STAT3 is a nuclear transcription factor that regulates genes involved in cell cycle, cell survival, and immune response. Although STAT3 activation drives cells to physiological response, its deregulation is often associated with the development and progression of many solid and hematological tumors as well as with drug resistance. STAT3 is a redox-sensitive protein, and its activation state is related to intracellular GSH levels. Under oxidative conditions, STAT3 activity is regulated by S-gluta...
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#1Zhongwu Su (SYSU: Sun Yat-sen University)H-Index: 1
#2Hao Xiong (SYSU: Sun Yat-sen University)H-Index: 7
Last.Yiqing Zheng (SYSU: Sun Yat-sen University)H-Index: 11
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Long noncoding RNA (lncRNA) disorder has been found in many kinds of age-associated diseases. However, the role of lncRNA in the development of age-related hearing loss (AHL) is still largely unknown. This study sought to uncover AHL-associated lncRNAs and the function. RNA-sequencing was conducted to profile lncRNA expression in the cochlea of an early-onset AHL mouse model. RT-qPCR assay was used to validate the expression pattern of lncRNAs. ATP assay, JC-1 assay, mitochondrial probe staining...
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#1Baoyu Yang (Liaoning University)H-Index: 1
#2Xiuli Lu (Liaoning University)H-Index: 8
Last.Bing Gao (Shenyang Medical College)H-Index: 12
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Crystal-cell interactions are a vital step toward kidney stone formation. However, its mechanisms remained unclear. Here, a protein-protein interaction (PPI) network analysis of a kidney stone revealed that the proteins were enriched in a posttranslational protein modification process in the endoplasmic reticulum (ER). The in vitro study showed that the markers of ER stress, including Bip and CHOP, were upregulated, PERK and ATF6 were activated, and XBP-1 mRNA was spliced. An ER stress-specific ...
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#1Anthony Cyr (University of Pittsburgh)
#2Lauran A. Chambers (University of Pittsburgh)
Last.Brian S. Zuckerbraun (University of Pittsburgh)H-Index: 42
view all 14 authors...
Background. Organ injury and dysfunction in sepsis accounts for significant morbidity and mortality. Adaptive cellular responses in the setting of sepsis prevent injury and allow for organ recovery. We and others have shown that part of the adaptive response includes regulation of cellular respiration and maintenance of a healthy mitochondrial population. Herein, we hypothesized that endotoxin-induced changes in hepatocyte mitochondrial respiration and homeostasis are regulated by an inducible n...
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#1Gregory A. Shilovsky (MSU: Moscow State University)
#2Oleg A. Zverkov (RAS: Russian Academy of Sciences)H-Index: 5
Last.Vassily A. Lyubetsky (RAS: Russian Academy of Sciences)H-Index: 10
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Cardiolipin interacts with many proteins of the mitochondrial inner membrane and, together with cytochrome C and creatine kinase, activates them. It can be considered as an integrating factor for components of the mitochondrial respiratory chain, which provides for an efficient transfer of electrons and protons. The major, if not the only, factor of cardiolipin maturation is tafazzin. Variations of isoform proportions of this enzyme can cause severe diseases such as Barth syndrome. Using bioinfo...
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#1Weijie Lv (SCAU: South China Agricultural University)H-Index: 2
Last.Shining GuoH-Index: 7
view all 10 authors...
Generally, depression is the result of complex gene-environment interactions. Recent studies have showed that the gut microbiota can affect brain function through the microbiota-gut-brain axis. However, the underlying mechanism of the microbiota and potential influence of depression remain elusive. We aimed to determine how gut microbiome contributes to the process of depression and further influences the host. Chronic unpredictable mild stress (CUMS) is used to establish a depression model. Fec...
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Top fields of study
Oxidative stress
Antioxidant
Reactive oxygen species
Biochemistry
Biology