High degree of polyclonality hinders somatic mutation calling in lung brush samples of COPD cases and controls
Abstract
Chronic obstructive pulmonary disease (COPD) is induced by cigarette smoking and characterized by inflammation of airway tissue. Since smokers with COPD have a higher risk of developing lung cancer than those without, we hypothesized that they carry more mutations in affected tissue. We called somatic mutations in airway brush samples from medium-coverage whole genome sequencing data from healthy never and ex-smokers (n = 8), as well as from...
Paper Details
Title
High degree of polyclonality hinders somatic mutation calling in lung brush samples of COPD cases and controls
Published Date
Dec 27, 2019
Journal
Volume
9
Issue
1
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