Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy
Abstract
Mutations in cardiac myosin binding protein C (MyBP-C, encoded by MYBPC3) are the most common cause of hypertrophic cardiomyopathy (HCM). Most MYBPC3 mutations result in premature termination codons (PTCs) that cause RNA degradation and a reduction of MyBP-C in HCM patient hearts. However, a reduction in MyBP-C has not been consistently observed in MYBPC3-mutant induced pluripotent stem cell cardiomyocytes (iPSCMs). To determine early MYBPC3...
Paper Details
Title
Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy
Published Date
Jan 30, 2020
Journal
Volume
5
Issue
2
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