SMARCB1/INI1 AND NUT IMMUNOEXPRESSION IN A LARGE SERIES OF ORAL AND OROPHARYNGEAL SQUAMOUS CELL CARCINOMAS

Objective Current evidences support that squamous cell carcinomas (SCCs) of the oral cavity (OSCC) and oropharynx (OPSCC) are distinct and unique, with differences on its pathogenesis, treatment, and prognosis. SMARCB1/INI1 is a potent tumor suppressor, whereas nuclear protein in testis (NUT) antibody identifies midline carcinoma (NMC), a rare aggressive carcinoma typically located on the midline of the head and neck. Although with different...