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Jorge Esquiche León
University of São Paulo
222Publications
16H-index
775Citations
Publications 256
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A white 47-year-old woman complained about a lesion in gingiva present for 2 months. Her medical history included systemic erythematosus lupus with previous use of corticosteroids. The intraoral examination revealed an irregularly shaped gingival ulcer in the upper posterior region. Radiographic examination showed no significant abnormalities. According to clinical and radiographic features, malignant or infectious lesions were hypothesized. After an incisional biopsy, microscopic evaluation rev...
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Nodular fasciitis (NF) is a benign/reactive myofibroblastic proliferative process with unknown etiology, which presents as a solitary, painless, fast-growth nodule, commonly located on the limbs and trunk; the head and neck region is affected between 10% and 20% of cases. Noteworthy, uncommon NF variants such as intravascular, intramuscular, cranial, ossifying, proliferative, and intradermal have been reported. A 64-year-old man was referred complaining of a painful swelling in the right side of...
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Juvenile spongiotic gingivitis (JSG) is an uncommon entity with a predominance for girls, with the majority of patients in the second decade of life. The idiopathic gingival papillokeratosis with crypt formation (IGPC), described in March of 2017, affects the maxillary attached gingiva of both genders in the second decade of life. A 19-year-old female patient came to our clinic complaining of "red gingiva." Oral examination showed diffuse erythema, edema, and bleeding on the marginal gingiva ass...
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Benign fibrous histiocytoma (BFH) is a benign mesenchymal neoplasm, composed of fibroblasts and histiocytes in variable proportions; it is uncommon to find BFH intraorally. To date, approximately 50 oral BFH cases have been reported; of them, 2 cases affected the palate. A 47-year-old female patient was referred for management of a slow-growing lesion in the soft palate region that appeared 1 year ago. The nodular lesion was asymptomatic, well delimited, firm, and covered by normal mucosa. Radio...
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Squamous cell carcinoma (SCC) with a rhabdoid phenotype (SCCRP) is an extremely rare entity in the maxillofacial region. To date, only 2 oral SCCRP cases have been reported. The presence of this phenotype is associated with a worse prognosis than conventional SCC. A 44-year-old man was referred presenting painful facial asymmetry evidenced by increase of volume in the left maxilla with several months of evolution. Computerized tomography examination showed extensive osteolytic lesion on the left...
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Carcinoma cuniculatum (CC) is a rare variant of oral squamous cell carcinoma (OSCC). To date, 50 cases of oral CC have been reported. A 67-year-old white female patient presented complaining of a painless tumor mass in the left mandibular body with several months of evolution. Previous dental history indicated extraction of teeth #37 and #38 and chronic osteomyelitis. Intraoral examination revealed an irregular exophytic mass in the region of the extracted teeth, which exhibited a yellow purulen...
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Neurofibroma is a common cutaneous benign tumor of neural origin, and sporadic cases of fatty variants have been reported. A 56-year-old white woman was referred for evaluation of a nonulcerated submucosal nodule on the hard palate with 2 years of duration without symptoms. Her medical and family history was noncontributory. Intraoral examination revealed a nodular submucosal mass covered by normal-appearing mucosa measuring 2 cm in greatest dimension and resilient in consistency. Radiographic e...
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Objective Tetraspanins are proteins involved in several cellular processes, including association with tumor progression. In this study, the immunoexpression of tetraspanins in head and neck squamous cell carcinoma (HNSCC) were assessed, aiming to evaluate the participation of these molecules in carcinogenesis. Study Design An immunohistochemical study was carried out using the tissue microarray technique to evaluate the tetraspanins CD9 and CD63. One hundred and twenty-one HNSCCs were analyzed ...
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Objective Oropharyngeal squamous cell carcinomas (OPSCCs), especially those expressing human papilloma virus (HPV), are associated with a better prognosis than HPV-negative OPSCC and oral squamous cell carcinoma (OSCC). Among them, OPSCC often presents nonkeratinizing and hybrid than keratinizing histologic subtypes, as well as higher proliferation index. Thus, this study aims to analyze the relationship of epithelial-mesenchymal transition (EMT) and cell proliferation markers in OPSCC and OSCC....
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