Original paper
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Abstract
In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinnings promoting aberrant T cell activation remain poorly understood. Here, we show that during islet autoimmunity an miR142-3p/Tet2/Foxp3 axis interferes with the efficient induction of regulatory T...
Paper Details
Title
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Published Date
Dec 13, 2019
Journal
Volume
10
Issue
1
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Notes
History