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Isabelle Serr
IsletImmunologyFOXP3AutoimmunityBiology
10Publications
5H-index
89Citations
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Publications 11
Newest
#1Martin G. SchermH-Index: 5
#2Isabelle SerrH-Index: 5
Last. Carolin Daniel (LMU: Ludwig Maximilian University of Munich)H-Index: 12
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In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinnings promoting aberrant T cell activation remain poorly understood. Here, we show that during islet autoimmunity an miR142-3p/Tet2/Foxp3 axis interferes with the efficient induction of regulatory T (Treg) cells, resulting in impaired Treg stability in m...
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#1Maike BeckerH-Index: 3
#2Isabelle SerrH-Index: 5
Last. Carolin Daniel (LMU: Ludwig Maximilian University of Munich)H-Index: 12
view all 10 authors...
Abstract Objective Obesity and type-2 diabetes (T2D) are metabolic diseases that represent a critical health problem worldwide. Metabolic disease is differentially associated with fat distribution, while visceral white adipose tissue (VAT) is particularly prone to obesity-associated inflammation. Next to their canonical function of immune suppression, regulatory T cells (Tregs) are key in controlling adipose tissue homeostasis. Towards understanding the molecular underpinnings of metabolic disea...
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#1Martin G. SchermH-Index: 5
#2Isabelle SerrH-Index: 5
Last. Carolin Daniel (LMU: Ludwig Maximilian University of Munich)H-Index: 12
view all 4 authors...
Abstract Background microRNAs (miRNAs) have emerged as critical contributors to immune regulation and homeostasis, and their dysregulation is involved in the aberrant differentiation and function of T cell subsets. In type 1 diabetes (T1D), the clinically overt disease is preceded by a presymptomatic phase which is marked by the presence of islet autoantibodies while the individual is still normoglycemic. Recent analyses revealed impaired regulatory T (Treg) cell induction from naive CD4+ T cell...
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T follicular helper (TFH) cells are an integral part of humoral immunity by providing help to B cells to produce high-affinity antibodies. The TFH precursor compartment circulates in the blood and TFH cell dysregulation is implied in various autoimmune diseases including type 1 diabetes (T1D). Symptomatic T1D is preceded by a preclinical phase (indicated by the presence of islet autoantibodies) with a highly variable progression time to the symptomatic disease. This heterogeneity points towards ...
1 CitationsSource
#1Isabelle SerrH-Index: 5
#2Carolin DanielH-Index: 12
Source
#1Isabelle SerrH-Index: 5
#2Martin G. SchermH-Index: 5
Last. Carolin DanielH-Index: 12
view all 27 authors...
Molecular checkpoints that trigger the onset of islet autoimmunity or progression to human type 1 diabetes (T1D) are incompletely understood. Using T cells from children at an early stage of islet autoimmunity without clinical T1D, we find that a microRNA181a (miRNA181a)–mediated increase in signal strength of stimulation and costimulation links nuclear factor of activated T cells 5 (NFAT5) with impaired tolerance induction and autoimmune activation. We show that enhancing miRNA181a activity inc...
12 CitationsSource
#1Stefanie Kälin (TUM: Technische Universität München)H-Index: 5
#2Maike BeckerH-Index: 3
Last. Carolin DanielH-Index: 12
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Summary Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3 + regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo...
17 CitationsSource
#1Isabelle SerrH-Index: 5
#2Rainer W. Fürst (TUM: Technische Universität München)H-Index: 8
Last. Carolin DanielH-Index: 12
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Abstract Aberrant immune activation mediated by T effector cell populations is pivotal in the onset of autoimmunity in type 1 diabetes (T1D). T follicular helper (TFH) cells are essential in the induction of high-affinity antibodies, and their precursor memory compartment circulates in the blood. The role of TFH precursors in the onset of islet autoimmunity and signaling pathways regulating their differentiation is incompletely understood. Here, we provide direct evidence that during onset of is...
14 CitationsSource
#1Isabelle SerrH-Index: 5
#2Rainer W. Fürst (TUM: Technische Universität München)H-Index: 8
Last. Carolin DanielH-Index: 12
view all 12 authors...
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a humanized mouse model.
36 CitationsSource
#1Isabelle SerrH-Index: 5
#2Füsun GökmenH-Index: 2
Last. Carolin DanielH-Index: 12
view all 5 authors...
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