DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways

Background Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. Here, we aimed to dissect CC subtype-specific methylation instability to understand underlying mechanisms and functions. Methods We have assessed genome-wide DNA methylation in the healthy normal colon mucosa (HNM), precursor...