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Clinical Epigenetics
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#1Johannes Achenbach (MHH: Hannover Medical School)H-Index: 5
#2Mathias Rhein (MHH: Hannover Medical School)H-Index: 9
Last.Matthias Karst (MHH: Hannover Medical School)H-Index: 26
view all 9 authors...
The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore useful in studying large well-characterized cohorts of a prototype of a somatoform disorder and in parallel as a functional somatic syndrome (FSS). This disorder is characterized by distressing and functionally disabling somatic symptoms with chronic pain as the most frequent and clinically relevant complaint. Pain is perceived by nociceptiv...
#1Matthew C. Sinton (BHF: British Heart Foundation)
#2David C. Hay (Edin.: University of Edinburgh)H-Index: 28
Last.Amanda J. Drake (BHF: British Heart Foundation)H-Index: 25
view all 3 authors...
Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 24% of the global adult population. NAFLD is a major risk factor for the development of cirrhosis and hepatocellular carcinoma, as well as being strongly associated with type 2 diabetes and cardiovascular disease. It has been proposed that up to 88% of obese adults have NAFLD, and with global obesity rates increasing, this disease is set to become even more prevalent. Despite intense research in this field, the molecular processes ...
#1Keiko MatsubaraH-Index: 13
#2Masatsune Itoh (Kanazawa Medical University)H-Index: 4
Last.Maki FukamiH-Index: 23
view all 11 authors...
Background Human 15q11–13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11–13. Here, we report DNA methylation status of 15q11–13 and other autosomal imprinted differentially methylated regions (iDMRs) in cases with various deletions within the PWS/AS-responsible region.
#1Gesa M. Richter (Humboldt University of Berlin)H-Index: 8
#2Jochen Kruppa (Humboldt University of Berlin)
Last.Henrik Dommisch (Humboldt University of Berlin)H-Index: 1
view all 11 authors...
The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammatory disease periodontitis and oral cancer. Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that aimed to identify biologically active methylation marks of the oral masticatory mucosa that are associated wi...
#1Cheng Liu (UQ: University of Queensland)H-Index: 5
#2Lochlan J. Fennell (UQ: University of Queensland)
Last.Vicki Whitehall (UQ: University of Queensland)H-Index: 24
view all 7 authors...
Background Sessile serrated adenomas (SSAs) are common polyps which give rise to 20–30% of colorectal cancer (CRC). SSAs display clinicopathologic features which present challenges in surveillance, including overrepresentation in young patients, proclivity for the proximal colon and rarity of histologic dysplasia (referred to then as SSAs with dysplasia, SSADs). Once dysplasia develops, there is rapid progression to CRC, even at a small size. There is therefore a clinical need to separate the “a...
#1Zongli Xu (NIH: National Institutes of Health)H-Index: 20
#2Rolv T. Lie (University of Bergen)H-Index: 52
Last.Jack A. Taylor (NIH: National Institutes of Health)H-Index: 55
view all 5 authors...
Background Isolated orofacial clefts are among the most common congenital birth defects. Although the underlying biological mechanisms remain largely unknown, clefts are thought to be complex disorders influenced by genetic, environmental, and potentially epigenetic factors.
#1Takeshi Niinuma (Sapporo Medical University)H-Index: 9
#2Hiroshi Kitajima (Sapporo Medical University)H-Index: 4
Last.Tomo Hatahira (Sapporo Medical University)H-Index: 3
view all 15 authors...
Background Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cancer (CRC).
#1Laura S. BlekerH-Index: 2
#2Jeannette Milgrom (University of Melbourne)H-Index: 40
Last.Susanne R. de RooijH-Index: 24
view all 9 authors...
Background Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children, possibly through epigenetic alterations. Current evidence is largely based on animal and observational human studies. Therefore, evidence from experimental human studies is needed. In this follow-up of a small randomized controlled trial (RCT), DNA-methylation was compared between children of women who had received cognitive behavioral therapy (CBT) for ...
#2Sanaa ChoufaniH-Index: 23
Last.Cynthia HawkinsH-Index: 56
view all 0 authors...
Histological grading of choroid plexus tumors (CPTs) remains the best prognostic tool to distinguish between aggressive choroid plexus carcinoma (CPC) and the more benign choroid plexus papilloma (CPP) or atypical choroid plexus papilloma (aCPP); however, these distinctions can be challenging. Standard treatment of CPC is very aggressive and often leads to severe damage to the young child’s brain. Therefore, it is crucial to distinguish between CPC and less aggressive entities (CPP or aCPP) to a...
#1H. Hattori (Tohoku University)H-Index: 4
#2Hitoshi Hiura (Tohoku University)H-Index: 9
Last.Tsutomu Ogata (Hamamatsu University)H-Index: 46
view all 11 authors...
Background Human-assisted reproductive technologies (ART) are a widely accepted treatment for infertile couples. At the same time, many studies have suggested the correlation between ART and increased incidences of normally rare imprinting disorders such as Beckwith-Wiedemann syndrome (BWS), Angelman syndrome (AS), Prader-Willi syndrome (PWS), and Silver-Russell syndrome (SRS). Major methylation dynamics take place during cell development and the preimplantation stages of embryonic development. ...
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