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Clinical Epigenetics
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#1Zongli Xu (NIH: National Institutes of Health)H-Index: 27
#2Rolv T. Lie (University of Bergen)H-Index: 54
Last.Jack A. Taylor (NIH: National Institutes of Health)H-Index: 58
view all 5 authors...
Isolated orofacial clefts are among the most common congenital birth defects. Although the underlying biological mechanisms remain largely unknown, clefts are thought to be complex disorders influenced by genetic, environmental, and potentially epigenetic factors. In blood samples from 2- to 3-day-old infants (n = 747) collected in a nationwide population-based study of orofacial clefts in Norway, we measured DNA methylation profiles for more than 450,000 CpGs and then conducted epigenome-wide a...
1 CitationsSource
#1Takeshi Niinuma (Sapporo Medical University)H-Index: 9
#2Hiroshi Kitajima (Sapporo Medical University)H-Index: 5
Last.Hiromu Suzuki (Sapporo Medical University)H-Index: 56
view all 15 authors...
Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cancer (CRC). CRC cell lines were transiently transfected with siRNAs targeting UHRF1, after which DNA methylation was analyzed using dot blots, bisulfite pyrosequencing, and Infinium HumanMethylation450 BeadChip assa...
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#1Laura S. BlekerH-Index: 3
#2Jeannette MilgromH-Index: 40
Last.Susanne R. de RooijH-Index: 25
view all 9 authors...
Background Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children, possibly through epigenetic alterations. Current evidence is largely based on animal and observational human studies. Therefore, evidence from experimental human studies is needed. In this follow-up of a small randomized controlled trial (RCT), DNA-methylation was compared between children of women who had received cognitive behavioral therapy (CBT) for ...
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#1Johannes Achenbach (MHH: Hannover Medical School)H-Index: 5
#2Mathias Rhein (MHH: Hannover Medical School)H-Index: 9
Last.Matthias Karst (MHH: Hannover Medical School)H-Index: 26
view all 9 authors...
The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore useful in studying large well-characterized cohorts of a prototype of a somatoform disorder and in parallel as a functional somatic syndrome (FSS). This disorder is characterized by distressing and functionally disabling somatic symptoms with chronic pain as the most frequent and clinically relevant complaint. Pain is perceived by nociceptiv...
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#1Cheng Liu (UQ: University of Queensland)H-Index: 6
#2Lochlan J. Fennell (UQ: University of Queensland)H-Index: 2
Last.Vicki L. J. Whitehall (UQ: University of Queensland)H-Index: 30
view all 7 authors...
Sessile serrated adenomas (SSAs) are common polyps which give rise to 20–30% of colorectal cancer (CRC). SSAs display clinicopathologic features which present challenges in surveillance, including overrepresentation in young patients, proclivity for the proximal colon and rarity of histologic dysplasia (referred to then as SSAs with dysplasia, SSADs). Once dysplasia develops, there is rapid progression to CRC, even at a small size. There is therefore a clinical need to separate the “advanced” SS...
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#1Gesa M. Richter (Humboldt University of Berlin)H-Index: 4
#2Jochen Kruppa (Humboldt University of Berlin)H-Index: 1
Last.Arne S. Schaefer (Humboldt University of Berlin)H-Index: 28
view all 11 authors...
The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammatory disease periodontitis and oral cancer. Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that aimed to identify biologically active methylation marks of the oral masticatory mucosa that are associated wi...
1 CitationsSource
#1Mikko Konki (Åbo Akademi University)H-Index: 1
#2Maia Malonzo (Aalto University)H-Index: 3
Last.Riikka Lund (Åbo Akademi University)H-Index: 18
view all 17 authors...
Alzheimer’s disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the diseas...
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#1Keiko MatsubaraH-Index: 14
#2Masatsune Itoh (Kanazawa Medical University)H-Index: 4
Last.Masayo KagamiH-Index: 18
view all 11 authors...
Human 15q11–13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11–13. Here, we report DNA methylation status of 15q11–13 and other autosomal imprinted differentially methylated regions (iDMRs) in cases with various deletions within the PWS/AS-responsible region. We performed array-based methylation analysis a...
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#1Matthew C. Sinton (BHF: British Heart Foundation)H-Index: 1
#2David C. Hay (Edin.: University of Edinburgh)H-Index: 29
Last.Amanda J. Drake (BHF: British Heart Foundation)H-Index: 27
view all 3 authors...
Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 24% of the global adult population. NAFLD is a major risk factor for the development of cirrhosis and hepatocellular carcinoma, as well as being strongly associated with type 2 diabetes and cardiovascular disease. It has been proposed that up to 88% of obese adults have NAFLD, and with global obesity rates increasing, this disease is set to become even more prevalent. Despite intense research in this field, the molecular processes ...
3 CitationsSource
Perinatal depressive symptoms have been linked to adverse maternal and infant health outcomes. The etiology associated with perinatal depressive psychopathology is poorly understood, but accumulating evidence suggests that understanding inter-individual differences in DNA methylation (DNAm) patterning may provide insight regarding the genomic regions salient to the risk liability of perinatal depressive psychopathology. Genome-wide DNAm was measured in maternal peripheral blood using the Infiniu...
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Top fields of study
DNA methylation
Epigenetics
Cancer research
Genetics
Biology